Manish Soni

The objective of this paper was to attempt to investigate a review the Development and evaluation of mouth dissolving antinflammatory tablet containing fenoprofen. MDT is used methods to improve patient’s compliance have always attracted scientists towards the development of fancy oral drug delivery systems. Among them, mouth dissolving drug delivery systems (MDDDS) have acquired an important position in the market by overcoming previously encountered administration problems and contributing to extension of patent life. In the present scientific scenario the drug delivery technology has become highly competitive and rapidly evolving with ever increasing demand. Fast dissolving tablet (FDT) is one such type of an innovative and unique drug delivery system which is swiftly gaining much attention in the research field of rapid dissolving technology. Oral route is the most expedient and safest route of drug delivery because of wide range of drugs are administered through this route. Recently researchers have developed fast dissolving tablet (FDT) which dissolve or disintegrate rapidly in mouth saliva without intake of water. This novel drug delivery such as FDT or MDT (mouth dissolving tablet) has overcome many disadvantages like dysphagia or non accessibility of water while travelling. When compared with conventional dosage form FDT can be a useful alternative as well. This review article contains different techniques used for preparing FDT, silent features, various patented technologies, and mechanism of super disintegration, challenges faced and the limitations.

The aim of this study is to enhance the solubility of poorly water soluble drugs via the mixed hydrotrophic solid dispersion strategy using ibuprofen as a model drug because Ibuprofen is absorbed after oral administration, it is critical to improve the dissolution rate to enhance the bioavailability, due to its low water solubility. Solid dispersions were prepared by mixed hydrotrphic method. In vitro dissolution studies showed remarkable improvement in solubility and drug dissolution profile of these new ibupro­fen solid dispersions over pure ibuprofen. It was observed that dissolution rate of ibuprofen enhanced to a great extent by solid dispersion technique using citric acid and urea as a hydrotrophic agents.The results indicates that mixed hydrotrophic solid dispersion may serve as a successful strategy for enhancing solubility of poorly water soluble drugs.