Mahadevamma L

Cancer is a disease of abnormal, uncoordinated, uncontrolled and purposeless cell division in any part of body. The leading cause of death in women is due to breast cancer that accounts for 12.7% around the globe. This study aims to describe the prescribing trends and possible avenues for improving of chemotherapy drugs in breast cancer patients. The prospective observational was conducted among 178 patients in the Medical Oncological Department of Apollo Multispecialty Hospital and Research Center for a period of 6 months. The data was assessed and evaluated using statistical tool. The number of patients receiving adjuvant, neoadjuvant and palliative therapy was 131,10 and 37 respectively. The most commonly prescribed drug as monotherapy in adjuvant, neoadjuvant and palliative therapy was paclitaxel (14.5%) or zoledronic acid (14.5%), trastuzumab (40%) and zoledronate (45.9%) respectively. The most commonly prescribed combinational regimens drug in adjuvant, neoadjuvant and palliative therapy was Cyclophosphamide with Docetaxel (15.30%), Cyclophosphamide with Docetaxel (20%) or cyclophosphamide with Epirubicin (20%) and Letrozole with zoledronate (21.6%). Dexamethasone, ondansetron and pantoprazole (100%) were co administered in all the patients during their chemotherapy cycles. The observed side effects were back pain, anemia, neutropenia, insomnia, anxiety, myalgia, cough. The prescribed chemotherapy drugs for the breast cancer meet the criteria of patient’s adherence. Breast cancer is a prevalent type of cancer that require long term therapy and monitoring to evaluate and refine the therapeutic regimen of breast cancer to provide the extension and better quality of life.

Chronic Kidney Disease (CKD) characterized by progressive decline in Glomerular Filtration Rate (GFR), is major public health issue associated with morbidity and mortality. Anaemia is one of the most common problems causing morbidity in patients with CKD while they are on dialysis.  Erythropoietin is a major advance in the management of anaemia in CKD which stimulates erythropoiesis by increasing proliferation and maturation of erythroid progenitors and thereby treats anaemia. Prescribing pattern, effectiveness and cost of erythropoietin therapy in patients with chronic kidney disease. This was a Prospective and Observational study conducted for 06 months after obtaining IEC from Apollo Multi-Specialty Hospital, Bengaluru. Patients were enrolled based on enrolment criteria. Data were analysed using suitable statistical tool. Of 152 patients enrolled, 77 (50.65%) patients were in the age group ≥ 60 years, second generation ESAs was mostly prescribed 119(78.28%) than third 01(0.65%) and first 32(21.05%). Significant increase in Haemoglobin, RBC, PCV was observed. We have demonstrated that ESAs were prescribed majorly in Nephrology compared to medicine department. Second generation ESAs were prescribed mostly, darbepoetin alfa 40mcg were preferred over other doses. The changes in Hb, PCV and RBC were significant suggesting ESAs as effective. The side effects reported were less, common and mostly unrelated to ESAs. Based on these finding, we suggest that ESAs is prescribed majorly in Nephrology and is effective and safe in managing anaemia of CKD.

The aim of this study is to find the usage of antimicrobials in hospital section and to study the frequency of morbidity and mortality. The present study was undertaken to screen rational use of antimicrobials in inpatient department (IPD). Prescriptions from medicine, surgery, obstetrics (OBG) were collected over a period of nine months. Prescriptions containing antimicrobial drugs were analyzed for appropriateness in dose, dosage, duration of therapy. In our study we found that, out of 362, 179 were males and 189 were females. In that most commonly Cephalosporinns 142 (39.22%), Quinolones 128 (35.35%), Antiprotozoal 63 (17.40%) followed by Macrolides, Aminoglycosides, Penicillines, and Anthelmentics were prescribed. Our findings indicate an urgent need for the establishment of proper guidelines, dissemination of information to practitioners and supervision of antimicrobial usage in low income countries like India. Irrational and unnecessary drug use can be expensive and harmful leading to resistance. Key words: Antimicrobials, Prescription, Health Care

Tuberculosis is a contagious infection caused by air borne bacteria Mycobacterium tuberculosis. Tuberculosis is a growing health problem in the developing world. India accounts for one-fifth of the global TB incident cases, each year nearly two million people in India develop TB1. This was a retrospective record based survey carried at AH & RC (Adichunchanagiri Hospital & Research Centre) Tertiary care teaching hospital, B.G Nagara. Twelve month data of all TB patients i.e. from Sep-09 to Aug-10 that were diagnosed in the Directly Observed Treatment Short Course Centre was taken, which included 120 diagnosed patients. Out of 120 patients diagnosed, the male to female ratio was 2.5:1, and 29 were from age group of 40 to 49 years. Pulmonary TB cases were more i.e. 85 (75.83%) when compared to extra pulmonary i.e. 35 (29.17%), new smear positive cases were 62 (51.67%) and new smear negative cases were 58 (48.33%). Total 67 (55.83%) patients were categorized in CAT-I, 25 (20.83%) patients in CAT-II and 28 (23.33%) in CAT-III.The Treatment Completion Rate (TCR) and rate of cure was not known since all patients were transferred to their nearest peripheral RNTCP/DOTS Centers, and those centers failed to provide proper feedback. So, for transferred TB cases a better system of follow up should be done in order to know about the TCR and rate of cure. Key Words: RNTCP/DOTS centre, Category, Tuberculosis, TCR (Treatment Completion Rate).