M.D.Dokhe

Throughout the last 20 years, several trendy technologies are established within the pharmaceutical analysis and development space. The automation of the drug drug discovery method by technologies like high output screening, combinatorial chemistry and computer aided drug design is resulting in a huge range of drug candidates possessing a very good efficacy. Unfortunately, several of drug candidates are a unit exhibiting poor liquid solubility. The use of drug nanocrystal is an universal formulation approach to extend the therapeutic performance of those medication in any route of administration. Drug nanocrystals are crystals with a size range in the nanometer range, meaning that they are nanoparticles with a crystalline character. This review describes the chemistry properties of drug nanocrystals, production method and potential clinical advantages. Poorly soluble medication are usually difficult drawback in drug formulation. Reducing the particle size of a drug to a nono-scale leads to an increased in surface area-to-volume ratio, increased dissolution velocity and improved in vivo performance of poorly soluble drugs.

Preformulation is a group of studies that focus on the physicochemical properties of a new drug candidate that could affect the drug performance and the development of a dosage form. This could provide important information for formulation design or support the need for molecular modification. Every drug has intrinsic chemical and physical properties which has been consider before development of pharmaceutical formulation. This property provides the framework for drugs combination with pharmaceutical ingredient in the fabrication of dosage form. Objective of Preformulation study is to develop the elegant, stable, effective and safe dosage form by establishing kinetic rate profile, compatibility with the other ingredients and establish physico-chemical parameter of new drug substances. Among these properties drug solubility, partition coefficient, dissolution rate, polymorphic forms and solubility are plays important role in Preformulation study. Polymorphism having crystal and amorphous forms shows different chemical, physical and therapeutic description of the drug molecule. This article explains some properties and therapeutic for Preformulation parameters of drug.