Hiral K Modi

Aegle marmelos, commonly known as Bael tree belonging to family Rutaceae is moderately sized, deciduous tree throught in dry forest hill of India & Central & Southern Asian countries. The different parts of plant contain numerous phytoconstituents like alkaloids, flavonoids, coumarins, essential oil etc. In this present study pharmacognostic evaluation is carried out which includes macroscopy, quantitative analysis & Phytochemical Screening. The various leaf extracts were subjected to preliminary phytochemical screening which will help in future for the standardization of formulation containing A.marmelos.

The present study was investigated the antioxidant activities of the various extracts of Aegle Marmelos (AM) belongs to family Rutaceae. The antioxidant activities of extracts have been evaluated by using a range of in vitro assays and in vivo hepatoprotective model. In vitro Antioxidant activity was evaluated by percentage inhibition in different assays  including  2, 2’-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl radical scavenging assay hydrogen peroxide radical scavenging assays, reducing power capacity. The extract exhibited potent antioxidant activity compared to known antioxidant. The extracts of A.Marmelos were tested for in vivo efficacy by carbon tetrachloride (CCl4) induced liver damage rats in hepatoprotective model. The in vitro antioxidant activities of extracts showed significant activities on reducing power, DPPH, hydroxyl radical and hydrogen peroxide nearer to control group based on IC50 values. Oral administration of various extracts of A.Marmelos resulted in significant improvement on the levels of malondialdehyde (MDA) and superoxide dismutase (SOD), Catalse (CAT) in liver homogenate & Significant increase in level of MDA which was intoxicated by CCl4. CCl4 produced significant alteration of serum marker enzymes, total bilirubin, total protein and liver weight. The extracts significantly restored of these values towards normal compared to control group. Due to its natural origin and potent free radical scavenging ability A.Marmelos could be used as a potential preventive intervention for free radical mediated diseases. Key words: DPPH, SOD, CAT, MDA, In Vivo & In Vitro Antioxidant assays

To evaluate the heapatoprotective activity of various extracts of Aegle Marmelos, belonging to the family Rutaceae against Carbon Tetrachloride (CCL4­) induced hepatootxicity in wistar Female rats. Oxidative stress play important role in many diseases. Hence, Herbal drugs play crucial role in treatment of various diseases due to its antioxidant property. The toxicant was used to induce hepatotoxicity at dose of CCl4  1.25 ml/kg of body weight as mixture of 1:1 with olive oil for 30 days. Experimental groups of were constructed: a vehicle control group received the respective vehicles; a CCl4 group received a repeated single oral dose of CCl4 at 1.25 ml/kg; and the CCl4 &AMPE, AMCL.AMAL, AMAQ received repeated oral dose of Aegel Marmelos extracts in 500 mg/kg, respectively. It was found that AMCL, AMAL & AMAQ, at a dose of 500 mg/kg body weight exhibited hepatoprotective effect by lowering the Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), alkaline phosphate and total bilirubin to a significant extent. The groups treated with various extract of A.Marmelos & Silyamarine shows significant (P