Hassan

Orthopedic is a branch of medicine dealing with the correction of deformities of bones or muscles. This research study aims to investigate the Health-Related Quality of Life (HRQOL) of Post-operative orthopedic patients and explore the factors that influence their HRQOL using WHO-BREF questionnaire, and by supplement counselling to address patient’s psychosocial needs and enhance their HRQOL. This study involved a sample of orthopedic patients who undergone various surgical procedures and were recruited from tertiary care hospital. The data was collected through interviews using WHO-BREF Questionnaire and analyzed using appropriate Statistical techniques. The findings contribute to a comprehensive understanding of the factors influencing the HRQOL of post-operative orthopedic patients, thereby highlighting the importance of incorporating counseling as a supportive measure in their care. Ultimately leading to enhanced patient outcomes and overall satisfaction. The P-value was found to be appropriate.

It is well-known that Atrial Fibrillation (AF) is the commonest type of cardiac arrhythmias. The risk factors for AF have been investigated for years however, lone AF is idiopathic which means that there is no definite cause or risk factors for it. It usually affects young age groups; and because all the risk factors have been overlooked, the link between ABO system and cardiac arrhythmias in general has not been investigated yet. Based on that, we decided to set this study to figure out the link between ABO blood group and lone AF.This case series study was conducted over a period of one year (September 2016 to September 2017). A consecutive non random sampling technique was adopted by pooling all the patients with AF attended the emergency department in two main teaching hospitals (Al-Yarmouk Teaching hospital and Baghdad Medical City Teaching Hospital) during the total year data collection period. A total of 100 patient (52 females and 48 males) was collected, all were diagnosed by the cardiologist to have lone AF, their ages ranged between (20-60) years. The mean age of the study group was (40.36 +10.90) years, means of Blood parameters were as follow: for blood group A; glucose was (5.20+0.98) mmol/L, creatinine (1.15+0.28) md/dl, Sodium (146.02+4.47) meq/L and potassium (4.45+0.41)meq /L, P value <0.1. For blood group B: (4.73+0.82) mmol/L, (0.85+0.12) md/dl, (141.33+6.03) meq/L, (4.36+0.52) meq/L, P <0.2. Blood group AB: (5.14+0.96) mmol/L, (0.97+0.29) mg/dl, (145.57+5.34) meq/L, (4.17+0.51) meq/L and P <0.1. Finally blood group O results: (5.2+1.07) mmol/L, (0.99+0.29) mg/dl, (142.52+6.28) meq/L, (3.88+0.70) meq/L, P <0.1. No statistical significance was found in any of these groups.People of blood group A are at a relatively higher risk to develop lone AF than O blood group and other non O blood groups. Key words: Lone Atrial Fibrillation, ABO blood groups, cardiac arrhythmias.  

The aim of the study was to evaluate the effect of different lubricants on pharmaceutical effectiveness of metronidazole tablets determined by the rate of release of drug from the dosage form. Different lubricants, like magnesium stearate, talc and the combination of both were used to prepare metronidazole tablets by direct compression method. The tablets were tested for quality control parameters such as uniformity of weight, thickness, diameter, contents assay, hardness, friability and disintegration time. Formulations were tested for the releasing pattern of drug from tablets by in-vitro dissolution test. Better results were achieved from formulation having magnesium stearate as lubricant based on compression force value. The content uniformity for all the three formulations was found in the range of 96.71 to 99.61%, while hardness was in the range of 7.39±0.341 to 10.375±0.95 Kg. The formulated tablets were also analyzed for dissolution profile which was more than 85% within 20 minutes. Then it was compared with dissolution profile of marketed products for quality and similarity analysis. Lubricant plays a key role in successful manufacturing of pharmaceutical solid dosage forms. Many failures in pharmaceutical manufacturing operations, directly or indirectly, can be controlled by appropriate screening of lubricants.

Recently, nutritional and pharmaceutical benefits of pomegranate have raised a growing scientific interest. Our present work aimed, for the first time, to investigate the importance of the Lebanese pomegranate molasses. For that, we determined the chemical composition of six samples of molasses provided from different sources to know their contents in secondary metabolites having medical importance. Then the antioxidant capacity has been evaluated for the six samples. Chemical composition of pomegranate molasses was determined using a standard phytochemical screening. Total phenolic and total flavonoids contents have been evaluated using the Folin-Ciocalteau reagent and the aluminum chloride method respectively. Finally, free radical scavenging activity of molasses was evaluated using DPPH assay. The obtained results of the phytochemical screening of molasses pomegranate indicated the presence of various secondary metabolites such phenols, flavonoids, resins, and saponin in the different studied molasses. Also, all samples showed a higher antioxidant capacity reaching 90 %. Considering properties of the identified major compounds with the higher antioxidant power of the studied samples, molasses pomegranate could be used in the medicine field including the food, pharmaceutical and cosmetic industry.

The adsorption of Murexide, Eosin yellowish and Bromo cresol green(BCG) dyes by CKD was carried out by varying the parameters such as contact time, dye concentration, adsorbent dose, pH and temperature. Adsorption isotherm equations were tested for all of Langmuir, Freundlich, Temkin, Modified Frumkin, Dobinin-Radushvich, Harkins-Jura and Elovich. The equilibrium adsorption data were fitted between Freundlich and Temkin isotherms for Murexide, D-R isotherm for Eosin yellowish and Freundlich for BCG. Adsorption followed pseudo-second-order rate kinetics. The high percentage removal was found ≈ 80.2% at 333K , pH 6  ;  ≈ 42% at 303K,  pH 6; and ≈ 50% at 303K, pH 5 of Murexide, Eosin yellowish and BCG respectively. Thermodynamic parameters ΔG, ΔH, ΔS and Ea were computed ,and showed that the  adsorption process onto CKD was endothermic and spontaneous in Murexide adsorption process, while in Eosin yellowish and BCG adsorption was exothermic and spontaneous. Also adsorption studies suggest that physisorption might be the major mode of adsorption and CKD expressed as low affinity for removal of Eosin yellowish and BCG  and  in general the adsorption process was less affected by temperature .

Geometry optimization calculations for (5z,5ˉz)-2,2ˉ- methylene bis (3-(5-mercapto-1,3,4-Thiadazole-2-yal)-2-(methyl -2,3-dihydro-1,3-oxazepine-4,7-dione), B, is carried out to establish a direct correspondence between experimental and theoretical by using density functional theory (DFT) with B3LYP/6-31G. The theoretical IR and 1H-NMR for the same molecule are performed at the same level of theory. These data suggest that the spectra of the thiadazole are consistent with the thiadazole architecture proposed by Abbas and co-workers. The investigation of HOMO and LUMO approved that this molecule is very suitable to be a semiconductor material because it's have a very low energy band gap equal to 0.13628 ev.

Hypertension is a global health problem with significant magnitude of morbidity and mortality, in recent years, most of the developing countries such as Sudan depend largely on the herbal remedies which are used for the treatment of hypertension such as: Hibiscus Sabdariffa. In folk medicine it is used for variety aspects such as: wound dressing, bronchitis and diabetes. The extract of this plant exerts its antihypertensive activity by at least three major specific mechanisms of action:  diuretic, vasodilator and angiotensin converting enzyme inhibitor (ACE inhibitor).The object of the work was to to discuss and evaluate the effectiveness of Hibiscus Sabdariffa as antihypertensive agent. In vitro, H. sabdariffa (HS) act as a vasodilator via relaxed the pre-contracted endothelium-intact and endothelium-denuded aortic rings. In man and laboratory animals, aqueous extraction of HS significantly reduced BP in essential hypertensive man, and the calyx extract reduced BP in the spontaneously hypertensive rat. It's also significantly reduced BP in normal rats and anesthetized cats. In addition, there are an evidence reports that the regular use of (HS) can protected the body from the cardiovascular disorder by lowering: total cholesterol, low-density lipoprotein cholesterol (LDL-C) and triglycerides in the majority of normolipidemic, hyperlipidemic and diabetic animal models. All the studies had agreed that Hibiscus Sabdariffa can significantly reduce the blood pressure, but all the problems that reported later on in the discussion that have founded on the conducted articles need further evaluation of this herbal remedy to be approved as an effective antihypertensive agent.

The aim of this study was to investigate the Hepatitis B immunity status of Biomedical Students of Usmanu Danfodiyo University Sokoto, North-Western Nigeria. CTK Biotech (USA) Onsite HBsAb ELISA kit was used for the determination of HBsAb status of subjects. We investigated the HBsAb status of 186 biomedical students aged ≥ 18 years (mean age 26 ± 2.0 years) made up of 147 males and 39 females. Out of 186 subject analyzed, 69 (37.1%) were Medical, 75(40.3%) were Medical Laboratory Science and 42(22.6%) were Nursing students. Age group distribution among these subject shows that majority 108(58.0%) were in the 21-25 years age group. Subjects were stratified based on marital status. Majority of subjects were single 173(93.1%) compared to married 13 (6.9%). Ethnic distribution of subjects indicated that 104(55.9%) were Hausa, 32 (17.2%) were Yoruba while 20(10.8%), 9(4.8%) and 21(11.3%) were Fulani, Igbo and other ethnic groups respectively. Among the 186 subjects studied, only 13(7.0%) has had prior complete course of hepatitis B vaccination (p=0.001). Protective HBsAb titre (>10miu/ml) was evident in 72(38.7%) of the subjects while 114 (61.3%) did not had no protective HBsAb titre (

Using natural adsorbants for the removal of dyes from solutions may represent a new and effective method of dye control and treatment. In this study, the adsorption of methyl orange by Lebanese Eryngiumcreticum was evaluated. Removal rates of methyl orange were determined by UV-Vis spectrophotometry and the adsorption process was found to be affected by initial dye concentration, adsorbant concentration, and pH. Adsorption isotherms were also plotted and showed a type III isotherm at pH 2, and a type V isotherm at pH 10. The adsorption of Eryngiumcreticum was then compared to other synthetic adsorbants and was found to offer similar adsorption capacity to some.

The various methods of synthesizing pyrazole and bipyrazole moieties have always been a subject of interest for medicinal chemists. Primarily, the pyrazoles have been synthesized from diketones, hydrazones, acetylenes and more recently from chalcones. The bipyrazoles in turn have been derived from pyrazoles. The important methods of synthesis including the recent techniques have been reported in this review.