G.Sammaiah

In the present study novel series of 3-((3-((6-benzoyl-1H-benz[d]imidazol-2-yl) amino)-5-mercapto-4H-1, 2, 4-triazol-4-yl)imino)substituted indolin-2-ones have been synthesized in good yields and characterized by IR, NMR and Mass spectral analyses. Compounds were evaluated for their preliminary in vitro cytotoxic activity against HCT-116 (colon), MCF-7 (breast), HeLa (cervical) and HepG2 (hepatocellular) cancer cell lines by standard MTT assay method, antioxidant activity by standard DPPH assay method and also were screened for  in vitro anti-inflammatory activity.

In the present study N-(2-oxosubstitutedindolin-3-ylidine)-2-phenylacetohydrazides (IV a-h) have been synthesized in good yields and characterized by IR, PMR and mass spectral analyses. Compounds were evaluated for their preliminary in vitro cytotoxic activity against HeLa cancer cell lines by standard MTT assay and also were screened for antioxidant activity by DPPH method. Our results shown that two of the analogues IVf and IVc  are potent antioxidant agents and IVb and IVg are potent cytotoxic agents.