Bijan Kumar Gupta

The purpose of the present study was to develop an optimized gastric floating once-daily matrix tablet of ofloxacin (FERMTs) using  hydrophilic polymers such as HPMC K4M, HPMC 100M, isapagulha husk and sodium bicarbonate as buoyancy contributer. The formulation of FERMTs were designed by 23full factorial design taking amount of HPMC K4M, HPMC 100M and sodium bicarbonate as formulation variables and prepared by wet granulation method. The FERMTs were then evaluated for hardness, friability, weight variation, content uniformity, in vitro drug release and floating capacity. Finally, the floating lag time (FLT) and cumulative % drug release at 4h, 8h, 12h and 16h were taken as response variables and the FERMT formulation was numerically optimized by 23full factorial design using Design-Expert software (version 8.1). The optimized formula showed excellent floating efficiency over a 16 h period with FLT of 2.80 mins and drug release over a period of 16 hour. Analysis of dissolution data showed that the kinetic of drug release followed Korsemeyer-peppas model.

  The purpose of the present study was to develop an optimized gastric floating extended release matrix tablet of Metformin hydrochloride (FERMTs) using a hydrophilic polymer, HPMC K4M, a hydrophobic polymer ethyl cellulose and sodium bicarbonate as buoyancy contributor. The formulation of FERMTs were designed by D-optimal mixture design taking % of HPMC K4M, ethyl cellulose and sodium bicarbonate as formulation variables and prepared by wet granulation method. The FERMTs were then evaluated for hardness, friability, weight variation, content uniformity, in vitro drug release and floating capacity. Finally, the floating lag time (FLT) and cumulative % drug release at 1h, 2h, 6h and 10h were taken as response variables and the FERMT formulation was numerically optimized by D-optimal mixture design using Design-Expert software (version 8.1). The optimized formula showed excellent floating efficiency over 10 h period with FLT of 9.61 mins. The release profile of optimized formula showed much closed similarity with that of USP reference dissolution profile (f2 value= 87.95). Analysis of dissolution data showed that the kinetic of drug release followed Korsemeyer-Peppas and Higuchi model.

  Stress is a biological response to aversive conditions that tend to threaten or perturb the homeostasis of the organisms. Stress is one of the basic factors in the etiology of number of diseases and stress has been postulated to be involved in pathogenesis of various diseases, such as psychiatric disorders like depression and anxiety, immune suppression, endocrine disorder like diabetes mellitus, impotency, cognitive dysfunction, peptic ulcer, ulcerative colitis and cardiovascular disorder like atherosclerosis and hypertension. So a mixture of herbal extracts like Arjuna, Ashwagandha, Brahmi and Shankhapushpi in equal ratios was microencapsulated using different types of wall polymers by non solvent addition method. Microcapsules were evaluated for their percentage yield, percentage actual drug content, percentage extract entrapment efficiency, flowability and drug release kinetics. Kollicoat SR 30 D and aluminium stearate were observed as effective in prevention of particle aggregation during phase separation.  Microcapsules were shown controlled drug release pattern for 12 hours due to the presence of Eudragit RS 100 and Eudragit RL 100. Both these wall polymers are responsible for controlling the drug release from microcapsules through diffusion in phosphate buffer medium having pH 7.4.