Ashutosh Mishra

Dyspepsia is a common disease and it is common in the community.  The  aim of this review is to know the information regarding dyspepsia, and to assess the frequency of various causes of dyspepsia. Dyspepsia is the commonest gastrointestinal problem affecting at least 25% of the population during a year. Its prevalence varies in different countries, depending upon the prevalence of Helicobacter pylori infection, obesity, drug - alcohol - tobacco intake and spices in diet. Dyspepsia is common in different surveys in western societies have recorded prevalence between 23 and 41%. For many people dyspeptic symptoms are an unavoidable part of living. A minority of those sufferers who do consult can become major consumers of resource. About 4% of general practice consultations are for dyspepsia and 2% of the entire adult population receive either an endoscopy or barium meal each year. Time lost from work and interference with quality of  life are more difficult to measure but are likely to be considerable.

Fast dissolving Tablets are disintegrating and/or dissolve rapidly in the saliva without the need for water. Some tablets are designed to dissolve in saliva remarkably fast, within a few seconds, and are true fast-dissolving tablets. Others contain agents to enhance the rate of tablet disintegration in the oral cavity, and are more appropriately termed fast-disintegrating tablets, as they may take up to a minute to completely disintegrate. Oral delivery is currently the gold standard in the pharmaceutical industry where it is regarded as the safest, most convenient and most economical method of drug delivery having the highest patient compliance. By the addition of piperine in the fast dissolving formulation, its bioavailability increases, hence dosing reduces.

Drug delivery through oral route is widely accepted through all over world. Mouth dissolving tablet is most suitable tablet than conventional tablet. The main characteristic which is in the favors of mouth dissolving tablet is that there is no need of water to take it. Due to this it become more suitable dosage form for pediatric and geriatric patients. Since bioavailability of mouth dissolving tablet is high than conventional tablet, and mixing of piperine with it make them much more advance dosage form. Due to the addition of piperine in the drug, the dose size is reduced, and enhanced the onset of action. Addition of piperine with norfloxacin also increase the antibacterial activity and make them more effective.