Abhimanyu Sharma

Plants play many important roles in the environment. Not only do they provide us with food and useful products, but also they play a main role in maintaining the ecological balance of nature, the food chain and the natural cycles and also have medicinal value. Laboratory evaluations were made to assess the study of primary metabolites of Tinospora cordifolia, belongs to the family menispemeacae. It contains chlorophyll, sugars, starch, protein, ascorbic acid and phenols in, leaves, stem, root and callus of the plant. Levels of plant metabolites are strongly affected via genetic and environmental factors. Different types of pests’ are causing changes in plant metabolite production. The results revealed the evidence of different infestation of the plant by common herbivores. In this manuscript we report primary metabolites of the Tinospora cordifolia along with the quantification after the pests’ effect.

The purpose of present work was to prepare a nimesulide-loaded liquid suppository using menthol and to study the effects of various penetration enhancers such as neem oil, tulsi oil and ethanol on the cumulative percentage release of nimesulide. The physicochemical properties such as gelation temperature and gel strength of various formulations composed of nimesulide, menthol and poloxamer 188 were investigated. The in vitro study of nimesulide delivered by the liquid suppositories composed of poloxamer 188, menthol and various concentrations of penetration enhancers were performed. The in vitro studies were performed using Keshary-Chein diffusion cell and Small wonder (Lyzer apparatus). The cumulative percentage release of nimesulide of each formulation were calculated and compared with the other formulations. The liquid suppository formulations containing neem oil 2% and tulsi oil 2% showed excellent release rate as compared to other formulations.