Synthesis and Characterization of Chitosan-g-PAMPS Graft Copolymer and its Applications in Drug Delivery of Sodium Diclofenac

Chitosan-g-AMPS was synthesized using free radical initiators and characterized by FTIR, PXRD, SEM and TGA analysis. The 2-acrylamido-2-methyl-1-propane sulphonic acid (AMPS) concentration has been optimized from 3.5 x 10-2  to 19.5 x 10-2 mol dm-3 to get maximum grafting of AMPS monomer onto chitosan. The FTIR spectral analysis proves the successful grafting and the PXRD spectra reveals the increase in crystallinity due to grafting of AMPS. SEM images exposed that smooth form of chitosan was changed into porous and fluffy structure after grafting. The cumulative drug diclofenac sodium release was studied in colonic medium. Delivery of drug was 13% and 55% during 4 h of assay in gastro-enteric and colonic system respectively and chitosan was dissolved about 53% and 65% in gastro-enteric and colonic system, respectively. The drug release behavior depends on the pH of medium as well as on the nature of beads, and AMPS grafted chitosan shows slow release of diclofenac sodium.