Floating with Bioadhesion:A Unique Expansion in Gastroretetive Drug Delivery System

Gastro retentive drug delivery system is benefited system in which dosage form retained in stomach prolong period of time and drug release long period of time. Floating system means that float over the surface of the gastric contents when the stomach is full but at the time stomach is empties and the tablet reaches the pylorus the buoyancy of the dosage may be decrease & bioadhesive system becomes dislodged from the stomach wall when the system is full but a floating -bioadhesive system would overcome these drawback of floating and bioadhesive system and improving the therapeutic effect of the drug involved.   So this Floating-bioadhesive dosage forms exhibit a unique combination of floatation and adhesion for prolonged residence in the Stomach. Currently this floating bioadhesive approach is not only used for tablets but also for microsphere, beads & other dosage forms. This review article focus on recently used combination approaches to deliver drug by gastrointestinal drug delivery like Bioadhesive and floating.