Transcorneal Permeation of Ketrolac Tromethamine by Amino Acid Transporters

The research involve formulation and evaluation of three different ophthalmic solutions of Ketorolac tromethamine with three different amino acid transporters. The prepared formulations were subjected to ex-vivo transcorneal permeation and cornea hydration studies through excised goat cornea and the results were compared with those of a prepared standard Ketorolac tromethamine ophthalmic solution. The trans corneal permeation studies were carried out by using an all glass Franz diffusion cell. The non-steroidal anti-inflammatory drug Ketorolac tromethamine ophthalmic solution is indicated for the temporary relief of ocular itching due to seasonal allergic conjunctivitis and also for the treatment of inflammation following cataract surgery. In the study, the three amino acid transporters used were Lysine, Phenylalanine and Valine which are responsible for protein synthesis and play a significant role in the process of maintaining structural and functional integrity of conjunctiva and retina. The results obtained from the permeation studies of conjugated physical mixtures of Ketorolac tromethamine with different amino acid transporters across the excised goat cornea were observed to exhibit enhanced permeation when compared with the permeation of Ketorolac tromethamine from the standard formulation.