Hepatoprotective Effect of Alpinia Officinarum on Hepatic Ischemia/Reperfusion Induced Injury in Rats

To study the hepatoprotective effect of chloroform extract of Alpinia officinarum at 200 and 400 mg/kg against hepatic ischemia/reperfusion injury. 24 male wistar rats were divided in to four groups. The normal control group, model control group and extract treated group (at a dose of 200 and 400 mg/kg) were orally fed with 1% DMSO, 1% sodium CMC in saline as vehicle for 21 days followed by ischemia/reperfusion on twenty second day. Blood and liver samples were obtained from all the animals on 22nd day for biochemical analysis of AST, ALT, ALP and LDH and histopathological studies were also performed. The results showed that the ischemia/reperfusion injury causes significant (p