A Review on Analytical Methods for Estimation of Quetiapine Fumarate, an Antipsychotic Drug.

Quetiapine fumarate is a new generation atypical antipsychotic drug indicated for the treatment of schizophrenia and related psychoses. Various analytical methods used for the estimation of quetiapine has been reviewed in this paper. These include Ultraviolet spectrometry, High performance thin layer chromatography, High performance liquid chromatography, Potentiometry, Polarography, Ion titrimetry and Voltametry to determine the amount of quetiapine fumarate in bulk drugs, pharmaceutical formulations and biological fluids. Stability indicating and impurity profiling methods for quetiapine are also described. These analytical methods can be used for qualitative and quantitative estimation of quetiapine and / or its related impurities or degradants in bulk, formulation and biological fluids.