estimation

Quetiapine fumarate is a new generation atypical antipsychotic drug indicated for the treatment of schizophrenia and related psychoses. Various analytical methods used for the estimation of quetiapine has been reviewed in this paper. These include Ultraviolet spectrometry, High performance thin layer chromatography, High performance liquid chromatography, Potentiometry, Polarography, Ion titrimetry and Voltametry to determine the amount of quetiapine fumarate in bulk drugs, pharmaceutical formulations and biological fluids. Stability indicating and impurity profiling methods for quetiapine are also described. These analytical methods can be used for qualitative and quantitative estimation of quetiapine and / or its related impurities or degradants in bulk, formulation and biological fluids.

Determination of duloxetine by various methods from various matrices is reviewed in this paper. The methods used consist of spectrofluorimetry, ultraviolet (UV) spectroscopy, thin layer chromatography (TLC), and high-performance liquid chromatography (HPLC). These methods were used to determine the amount of duloxetine in bulk drugs, pharmaceutical dosage forms and biological matrix. HPLC with UV detector as well as mass spectrometric (MS) detector was used for evaluation of pharmacokinetics of duloxetine. It is concluded that HPLC-UV is the most reliable and applicable method for estimation in bulk drugs and formulations while LC-MS is widely employed in bioanalysis.   Keywords: duloxetine, analysis, estimation