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RP-HPLC Technique for the Assurance of Mebendazole In Unadulterated and In Tablet Measurements
Published in February 2020 Issue 1 (Vol. 10, Issue 1, 2020)
Abstract
A new RP-HPLC method for the assay of mebendazole in in unadulterated and in tablet measurements has been developed and validated. The present chromatographic study was carried on μ Bondapak® C18 (250X4.6 mm), 5μm with a flow rate of 1.0mL/min of mobile phase and UV detection at of 218nm and ambient column temperature with mobile phase of NaH2PO4 buffer(pH-5.0) and acetonitrile in the ratio of 65:35%v/v as the mobile phase. The retention time for mebendazole were found to be 2.60mins respectively. The developed RP-HPLC method was validated as per ICH guidelines and was found to be suitable for pharmacokinetic studies.
Authors (2)
M.Gopala Krishna
Acharya Nagarjuna University, ...Acharya Nagarjuna University, Guntur, A.P, IndiaAcharya Nagarjuna University, Guntur, A.P, IndiaAcharya Nagarjuna University, Guntur, A.P, India
View all publications →M.Subba Rao
Acharya Nagarjuna University, ...Acharya Nagarjuna University, Guntur, A.P, IndiaAcharya Nagarjuna University, Guntur, A.P, IndiaAcharya Nagarjuna University, Guntur, A.P, India
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Article Information
Published in:
February 2020 Issue 1 (Vol. 10, Issue 1, 2020)- Article ID:
- AJPTR101017
- Paper ID:
- AJPTR-01-002347
- Published Date:
- 2020-02-01
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How to Cite
Krishna & Rao (2020). RP-HPLC Technique for the Assurance of Mebendazole In Unadulterated and In Tablet Measurements. American Journal of PharmTech Research, 10(1), xx-xx. DOI:https://doi.org/10.46624/ajptr.2020.v10.i1.017
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