FORMULATION AND EVALUATION OF ENTERIC COATED MICROSPHERES OF PROTON PUMP INHIBITOR: IN-VIVO CHARACTERIZATION

  Pantoprazole Sodium sesquihydrate is a proton pump inhibitor that belongs to group benzimidazole, used for the treatment of ulcers in duodenum and gastric, which was degraded in stomach .Thus, the purpose of the study is to formulate a dosage form which is coated by coating polymer(s) which passed the acidic medium and exhibit significant effect in intestine and cures ulcers. An attempt was made to formulate micro particles with two coating polymers: Eudragit L-100 & Cellulose acetate phthalate as well as using of mucoadhesive polymers will release drug in controlled manner. Thus, these different types of micro particles was characterized in terms of Particles size, Mucoadhesive efficiency, Entrapment efficiency, In-vitro as well as In-vivo studies.   Key words: - Pantoprazole, Coating polymers, Mucoadhesive polymers