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📢 Latest Update: New special issue call for papers on "Emerging Technologies in Research" - Submit by March 31, 2025

📢 Latest Update: New special issue call for papers on "Emerging Technologies in Research" - Submit by March 31, 2025

October 2011 Issue 3

Volume 1, Issue 3 - $2011

Volume 1 Issue 3 Cover

Issue Details:

Volume 1 Issue 3
Published:Invalid Date

Editorial: October 2011 Issue 3

Welcome to the 2011 issue of American Journal of PharmTech Research. This issue showcases the remarkable breadth and depth of contemporary research across multiple disciplines. From cutting-edge applications of machine learning in climate science to the revolutionary potential of quantum computing in drug discovery, our featured articles demonstrate the power of interdisciplinary collaboration in addressing global challenges.

We are particularly excited to present research that bridges traditional academic boundaries, reflecting our journal's commitment to fostering innovation through cross-disciplinary dialogue. The integration of artificial intelligence with environmental science, the application of blockchain technology to supply chain management, and the convergence of urban planning with smart city technologies exemplify the transformative potential of collaborative research.

As we continue to navigate an era of rapid technological advancement and global challenges, the research presented in this issue offers both insights and solutions that will shape our future. We thank our authors, reviewers, and editorial board members for their continued dedication to advancing knowledge and promoting scientific excellence.

Dr Hemangi J Patel
Editor-in-Chief
American Journal of PharmTech Research

Articles in This Issue

Showing 21 of 21 articles
Research PaperID: AJPTR013016

A REVIEW ON PHARMACEUTICAL APPLICATIONS OF LIQUISOLID TECHNIQUE

Narender Thakur, Sukhbir Lal Khokra, Dharmesh Sharma, Naseeb Singh Thakur, Rahul Purohit, Vikrant Arya

The term “liquisolid medication” implies oily liquid drugs and solutions or suspensions of water insoluble drugs carried in suitable non-volatile solvent systems. Liquisolid compacts demonstrated a considerably higher drug dissolution rates than those of conventionally made capsules and directly compressed tablets. This was due to the increased wetting properties and surface of drug available for dissolution. This review paper highlights the application of liquisolid technique to enhance the solubility and dissolution of water insoluble drugs. This technique is appropriate for poorly or water insoluble drugs and also for immediate or sustained release formulations. This review also depicts the various formulation parameters that must be optimized before formulation the liquisolid compacts.

Liquisolid techniqueSolubilityDissolutionPoorlyWater insoluble drugs
3,363 views
1,053 downloads

Contributors:

 Narender Thakur
,
 Sukhbir Lal Khokra
,
 Dharmesh Sharma
,
 Naseeb Singh Thakur
,
 Rahul Purohit
,
 Vikrant Arya
Research PaperID: AJPTR013017

REVIEW ON HYDROGEL NANOPARTICLES IN DRUG DELIVERY

Hiren B. Patel, Hardik L. Patel, Zeel H. Shah, Moin K. Modasiya

  Hydrogel nanoparticles have gained considerable attention in recent years as one of the most promising nanoparticulate drug delivery systems owing to their unique potentials via combining the characteristics of a hydrogel system with a nanoparticle. Therefore, it seems that the pharmacy world will benefit from the hydrophilicity, flexibility, versatility, high water absorptivity, and biocompatibility of these particles and all the advantages of the NPs, mainly long life span in circulation and the possibility of being actively or passively targeted to the desired bio-phase. Several polymeric hydrogel nanoparticulate systems have been prepared and characterized in recent years, based on both natural and synthetic polymers, each with its own advantages and drawbacks. Several cross linking methods have been used in the way to form the hydrogel matrix structures. The remainder of this text presents various types of nanogels prepared and characterized, using a classification based on the type of polymeric materials used in preparation of the NPs.   Key words: Hydrogel, Nanoparticles, Hydrogel nanoparticles, Nanogels, Hydrogel.

HydrogelNanoparticlesHydrogel nanoparticlesNanogelsHydrogel.
3,481 views
1,102 downloads

Contributors:

 Hiren B. Patel
,
 Hardik L. Patel
,
 Zeel H. Shah
,
 Moin K. Modasiya
Research PaperID: AJPTR013018

CURCUMIN: PROPERTIES AND MEDICINAL APPLIATION

Moin K. Modasiya, Vishnu. M. Patel

  Turmeric, derived from the plant Curcuma longa, is a gold-colored spice commonly used in the Indian subcontinent, not only for health care but also for the preservation of food and as a yellow dye for textiles. Curcumin, which gives the yellow color to turmeric, was first isolated almost two centuries ago, and its structure as diferuloylmethane was determined in 1910. Since the time of Ayurveda (1900 bc) numerous therapeutic activities have been assigned to turmeric for a wide variety of diseases and conditions, including those of the skin, pulmonary, and gastrointestinal systems, aches, pains, wounds, sprains, and liver disorders. Extensive research within the last half century has proven that most of these activities, once associated with turmeric, are due to curcumin. These include its anti-inflammatory, anti-oxidant, anti-carcinogenic, anti-mutagenic, anti-coagulant, anti-fertility, anti-diabetic, anti-bacterial, anti-fungal, anti-protozoal, anti-viral, anti-fibrotic, anti-venom, anti-ulcer, hypotensive and hypocholesteremic activities. Its anti-cancer effect is mainly mediated through induction of apoptosis. Its anti-inflammatory, anti-cancer and anti-oxidant roles may be clinically exploited to control rheumatism, carcinogenesis and oxidative stress-related pathogenesis. Thus, curcumin has the potential for the development of modern medicine for the treatment of various diseases.   Key words : Curcumin, diferuloylmethane, medicinal properties.

Curcumindiferuloylmethanemedicinal properties.
3,926 views
1,151 downloads

Contributors:

 Moin K. Modasiya
,
 Vishnu. M. Patel
Research PaperID: AJPTR013019

GASTRORETENTIVE DOSAGE FORMS: CURRENT DEVELOPMENTS IN NOVEL SYSTEM DESIGN AND EVALUATION

Praveen Khirwadkar, Kamlesh Dashora

  This review explains the recent advances in gastroretentive drug delivery systems with special focus on floating drug delivery systems. Oral controlled release (CR) dosage forms (DF) have been extensively used to improve therapy of many important medications. However, in the case of narrow absorption window drugs, this pharmaceutical approach cannot be utilized, as it requires sufficient colonic absorption of the drug (which contradicts the definition of narrow absorption window agents). On the other hand, incorporation of the drug into a CR delivery system, which releases its payload in the stomach over a prolonged time period, can lead to significant therapeutic advantages owing to various pharmacokinetic (PK) and pharmacodynamic aspects. Gastroretentive dosage forms (GRDFs) are a drug delivery formulation that are designed to be retained in the stomach for a prolonged time and release there their active materials and thereby enable sustained and prolonged input of the drug to the upper part of the gastrointestinal (GI) tract. This technology has generated enormous attention over the last few decades owing to its potential application to improve the oral delivery of some important drugs for which prolonged retention in the upper GI tract can greatly improve their oral bioavailability and/or their therapeutic outcome. This article reviews some of the latest developments in GRDF technology from a pharmaceutical point of view. It also highlights the PK and/or pharmacodynamic rationale for the development of GRDFs for certain drugs that are either absorbed in the upper GI tract or have local activity there.   Key words: Floating drug delivery systems, single unit, multiple units, gastric resident time, Expandable Systems

Floating drug delivery systemssingle unitmultiple unitsgastric resident timeExpandable Systems
3,774 views
1,174 downloads

Contributors:

 Praveen Khirwadkar
,
 Kamlesh Dashora
Research PaperID: AJPTR013020

REVIEW: CHAGAS DISEASE

Umesh S. Pal, Mrunal K. Shirsat, Indrajeet J. Singhvi, Manoj Verma, Nikhil Shah

  There are several species of trypanosomes, which are single-celled organisms. Some affect primarily animals, but some are a significant cause of human illnes. Trypanosomes are transmitted by insect bites; Chagas disease is transmitted by bites of the reduviid bug. It is estimated that 16 to 18 million people are infected with T. cruzi and that 30 to 40 percent will develop heart symptoms as a result of their infection. In parts of the world where Chagas disease is endemic, most notably South America, the disease is the largest single cause of cardiovascular death. Chagas disease is very rare in the United States; only eight cases have been reported, and all of these in Latin American immigrants.Conditions resulting from Chagas disease also include atrioventricular block, which is a failure of the normal conduction of the electrical impulses which control the heartbeat. Eighteen of the 25 patients with Chagas disease were under treatment for heart disease prior to their proper diagnosis. In one case, a patient had been treated for 10 prior to the diagnosis.

Mal de Chagas-MazzaChagasTrypanosomes cruziAmerican trypanosomiasisBrazilian Trypanosomiasisheart disease.
4,080 views
1,189 downloads

Contributors:

 Umesh S. Pal
,
 Mrunal K. Shirsat
,
 Indrajeet J. Singhvi
,
 Manoj Verma
,
 Nikhil Shah
Research PaperID: AJPTR013021

COLLOIDAL DRUG DELIVERY SYSTEMS: A FUTURE PROSPECTIVE FOR TREATMENT OF TUBERCULOSIS

Ankur Bhardwaj, Lalit Kumar, Veenu

  Colloidal Drug Delivery system is an advancing technology expected to bring revolutionary changes in the field of pharma and health sciences including drug delivery, diagnostics and treatment. The advancement in colloidal drug delivery systems helps in preparing newer formulations which become useful for treatment of tuberculosis. Development of Metered dose inhaler (MDT) and Directly Observed Therapy (DOTS) also proves to helpful in treatment of tuberculosis. Various colloidal drug delivery systems liposomes, niosomes, nanoparticles and microparticles proves to be a successful tool for tuberculosis treatment. One of the preparations like microemulsions results in theimprovement of bioavailability of the drugs. Similarly corticosteroids also found to be an interesting tool here because corticosteroids reduced the risk of pleural thickening in tuberculosis patients. These various colloidal drug delivery systems minimize the problems of conventional therapy like poor penetration, drug resistance, systemic toxicity and also main the improved drug delivery. This article describes the applications of various formulations along with their future aspects in treatment of tuberculosis.  

TuberculosisLiposomesNanoparticlesNiosomesDOTS.
4,186 views
1,208 downloads

Contributors:

 Ankur Bhardwaj
,
 Lalit Kumar
,
 Veenu
Research PaperID: AJPTR013022

FACTORS AFFECTING OBESITY IN MODERNIZED RURAL HIMACHAL

Dharmesh Sharma, Madhu Chauhan, Ruchika Chauhan, BrijeshKumar Duvey, Yashwant Singh, Pankaj Soni

  This community based study assessed the prevalence of obesity and associated factors among age group between 16 to 75 years. The obese and overweight subjects were from age group from 31 to 45 year which was 42.42% and 28.78% respectively and most of them were in sedentary jobs. Obese and overweight dipsomaniac smokers were from the age group46-60 year which was 90%. Prevalence of hypertension and diabetes among overweight elderly was observed in this study. Key words: Obesity, Overweight, Dipsomaniac, Hypertension, Diabetes

ObesityOverweightDipsomaniacHypertensionDiabetes
4,214 views
1,328 downloads

Contributors:

 Dharmesh Sharma
,
 Madhu Chauhan
,
 Ruchika Chauhan
,
 BrijeshKumar Duvey
,
 Yashwant Singh
,
 Pankaj Soni
Research PaperID: AJPTR013023

SPECTROFLUORIMETRIC DETERMINATION OF CELECOXIB IN BULK AND FORMULATIONS

Sunil Kumar Dubey, Chiranjeevi Venkatesh K, Jangala Hemanth

  A simple, rapid and economical spectrofluorimetric method for estimation of Celecoxib, a selective COX-2 inhibitor, in bulk and solid dosage forms was developed in the present study. Celecoxib shows maximum excitation intensity at 245 nm and maximum emission intensity at 382 nm which is used in this study. The linear regression equation obtained by least square regression method, was Int =0.253*Conc. (in ng/ml) +34.80. The method provides a linear response across a quantization range of 250ng/ml to 4000ng/ml. The developed method was employed with a high degree of precision and accuracy for the estimation of total drug content in three commercial capsule formulations of Celecoxib. The results of analysis were treated statistically, as per International Conference on Harmonisation (ICH) guidelines for validation of analytical procedures. The results were found to be accurate, reproducible and free from interference.  

CelecoxibSpectrofluorimeterRecovery Studies
4,515 views
1,398 downloads

Contributors:

 Sunil Kumar Dubey
,
 Chiranjeevi Venkatesh K
,
 Jangala Hemanth
Research PaperID: AJPTR013024

HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHIC METHOD FOR DETERMINATION OF TADALAFIL IN TABLET DOSAGE FORM

Satish A. Patel, Natvarlal J. Patel

  A simple and sensitive high performance thin layer chromatography (HPTLC) method has been developed for the quantitative estimation of Tadalafil in its single component tablet formulation (20 mg). Tadalafil was chromatographed on silica gel 60 F254 TLC plate using chloroform: methanol (9:1, v/v) as mobile phase. Tadalafil showed Rf value 0.78 + 0.008 and scanned at 285 nm using a camag TLC scanner 3. The method was validated in terms of linearity (100 – 800 ng/spot), precision (intra-day variation, 0.38 to 0.81% and inter-day variation, 0.45 to 1.90%), accuracy (100.3 ± 0.76) and specificity. The limit of detection and limit of quantification for Tadalafil were found to be 28.11 ng/spot and 93.45 ng/spot, respectively. The developed method was successfully used for the assay of Tadalafil tablet formulation. The method was found to be simple, sensitive, specific, accurate and precise and can be used for the routine quality control testing of Tadalafil in tablet dosage form.

TadalafilHPTLCvalidationtablet
4,570 views
1,336 downloads

Contributors:

 Satish A. Patel
,
 Natvarlal J. Patel
Research PaperID: AJPTR013025

FORMULATION AND EVALUATION OF ENTERIC COATED MICROSPHERES OF PROTON PUMP INHIBITOR: IN-VIVO CHARACTERIZATION

H. J. Patel, J. S. Patel, A. K. Sony, P Tiwari

  Pantoprazole Sodium sesquihydrate is a proton pump inhibitor that belongs to group benzimidazole, used for the treatment of ulcers in duodenum and gastric, which was degraded in stomach .Thus, the purpose of the study is to formulate a dosage form which is coated by coating polymer(s) which passed the acidic medium and exhibit significant effect in intestine and cures ulcers. An attempt was made to formulate micro particles with two coating polymers: Eudragit L-100 & Cellulose acetate phthalate as well as using of mucoadhesive polymers will release drug in controlled manner. Thus, these different types of micro particles was characterized in terms of Particles size, Mucoadhesive efficiency, Entrapment efficiency, In-vitro as well as In-vivo studies.   Key words: - Pantoprazole, Coating polymers, Mucoadhesive polymers

PantoprazoleCoating polymersMucoadhesive polymers
4,565 views
1,300 downloads

Contributors:

 H. J. Patel
,
 J. S. Patel
,
 A. K. Sony
,
 P Tiwari
Research PaperID: AJPTR013026

DEVELOPMENT AND VALIDATION OF SPECTROPHOTO-METRIC METHOD FOR SIMULTANEOUS DETERMINATION OF OFLOXACIN AND CEFPODOXIME PROXETIL IN TABLETS

Sanket A. Patel, Satish A. Patel

  The present manuscript describe simple, sensitive, rapid, accurate, precise and economical spectrophotometric method for the simultaneous determination of Ofloxacin and Cefpodoxime proxetil in combined tablet dosage form. The method is based on the simultaneous equations for analysis of both the drugs using methanol as solvent. Ofloxacin has absorbance maxima at 297 nm and cefpodoxime proxetil has absorbance maxima at 236.2 nm in methanol. The linearity was obtained in the concentration range of 2-12 μg/ml and 4-24 μg/ml for Ofloxacin and Cefpodoxime proxetil, respectively. The concentrations of the drugs were determined by using simultaneous equations at both the wavelengths. The mean recovery was 99.63 ± 0.47 and 99.57 ± 0.36 for Ofloxacin and Cefpodoxime proxetil, respectively. The method was successfully applied to pharmaceutical dosage form because no interference from the tablet excipients was found. The suitability of this method for the quantitative determination of Ofloxacin and Cefpodoxime proxetil was proved by validation. The proposed method was found to be simple and sensitive for the routine quality control application of Ofloxacin and Cefpodoxime proxetil in pharmaceutical tablet dosage form. The results of analysis have been validated statistically and by recovery studies.   Key words: Cefpodoxime proxetil, Ofloxacin, recovery, simultaneous equations method, tablet, validation.

Cefpodoxime proxetilOfloxacinrecoverysimultaneous equations methodtabletvalidation.
4,600 views
1,339 downloads

Contributors:

 Sanket A. Patel
,
 Satish A. Patel
Research PaperID: AJPTR013027

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW (E)-4-CHLORO-2-((3-(SUBSTITUTED ARYL)-1-PHENYL-1H-PYRAZOLE-4-YL) METHYLENE AMINO)-6-METHOXY PYRIMIDINE-5-CARBALDEHYDE DERIVATIVES

Jabali J. Vora, Akash R. Patel, Dinesh R. Patel, Sandip Dholakiya

Schiff Base derivatives are important class of compounds. They possess different types of Biological activities like antibacterial, antiviral, anti HIV, antifungal etc. Schiff base derivatives are prepared by the condensation of aldehyde and amine and these compounds are characterized by chemical and instrumental methods. Their important biological properties have been investigated. Key words: Schiff Base derivatives, Biological study, pyrimidine derivatives, Hydrazone derivatives

Schiff Base derivativesBiological studypyrimidine derivativesHydrazone derivatives
4,966 views
1,436 downloads

Contributors:

 Jabali J. Vora
,
 Akash R. Patel
,
 Dinesh R. Patel
,
 Sandip Dholakiya
Research PaperID: AJPTR013028

COMPARATIVE STUDY OF ACYCLOVIR SOLID DISPERSION FOR BIOAVAILABILITY ENHANCEMENT

Kushwaha Anjali, Prajapati Sunil K, Sharma Bhawna

  The objective of present study is to improve the dissolution rate of Acyclovir a poorly water soluble drug by solid dispersion technique using a water soluble carrier, PEG-6000, urea, mannitol. The solid dispersions are prepared by physical method, co-grinding method and solvent evaporation method. The prepared solid dispersions showed an enhancement in dissolution rate and solubility compared to plain drug. In vitro release profiles of all SDs were comparatively evaluated and also studied against pure acyclovir. Faster dissolution was exhibited by solid dispersion containing 1:4 ratio of drug: PEG-6000. The increase in dissolution rate of the drug may be due to increase in wettability, hydrophilic nature of the carrier and due to reduction in drug crystallinity. The prepared solid dispersion was subjected for % practical yield, drug content, infrared (IR) spectroscopic, differential scanning calorimetry (DSC). FT‐IR spectra revealed no chemical incompatibility between drug and PEG-6000.Drug– polymer interaction was investigated using differential scanning calorimetry (DSC) studies. Key words: Solid dispersions, carriers, solubility enhancement, poorly soluble drugs, bioavailability

Solid dispersionscarrierssolubility enhancementpoorly soluble drugsbioavailability
5,036 views
1,571 downloads

Contributors:

 Kushwaha Anjali
,
 Prajapati Sunil K
,
 Sharma Bhawna
Research PaperID: AJPTR013029

STABILITY INDICATING HPLC ASSAY METHOD FOR DIACEREIN AND ACECLOFENAC IN TABLETS

Krishna R Gupta, Varun E. Samrit, Anuradha H Mahapatra, Sudhir G.Wadodkar

  The present work describes the development of stability indicating assay method for Diacerein and Aceclofenac in their combined dosage form that would provide helpful information to the manufacturers. Stress studies were conducted on the drug substance and product under the ICH prescribed stress conditions viz. hydrolysis, oxidation, humidity, photolysis, thermal stress. The separation of the drug from its degradation products, trials were made by taking acetonitrile: water, acetonitrile: phosphate buffer, acetonitrile: phosphoric acid in various blends. Separation was achieved using C-18 column and a mobile phase comprising of Acetonitrile: Phosphoric acid 0.1 M (61: 39) at a flow rate of 1.5 mL/min. The detection wavelength was 260 nm. The drug showed sufficient decomposition under alkaline hydrolysis (0.05 N NaOH), acidic hydrolysis (0.05 N HCl), neutral hydrolysis (distilled water), and oxidative hydrolysis (6% H2O2). The drug was found to be moderately sensitive to humidity studies (75 % RH), photochemical studies (UV 254 nm), and thermal studies (600C). Recovery studies were also carried out for both the drugs and the mean percent recovery were found to be 100.69 for diacerein and 99.15 for aceclofenac. Mean percent estimation in marketed formulation gave 99.63% for diacerein and 100.04% for aceclofenac. The above method was validated for accuracy, precision, ruggedness, limit of detection, limit of quantitation and was found to be satisfactory for routine analysis of diacerein and aceclofenac in their combined dosage form in the presence of their degradation products.   Key words: Aceclofenac, Diacerein, Stress Degradation, Stability Indicating, Validation

AceclofenacDiacereinStress DegradationStability IndicatingValidation
5,022 views
1,637 downloads

Contributors:

 Krishna R Gupta
,
 Varun E. Samrit
,
 Anuradha H Mahapatra
,
 Sudhir G.Wadodkar
Research PaperID: AJPTR013030

DEVELOPMENT AND VALIDATION OF ULTRAVIOLET, RP-HPLC AND HPTLC METHODS FOR ESTIMATION OF TRAPIDIL BULK AND IN PHARMACEUTICAL FORMULATION

T.Sudha, V. Vengadesh, V.Ganesan

  Quantitative estimation of Trapidil and its pharmaceutical dosage form by HPLC, HPTLC and UV spectroscopy methods was developed. In the RP-HPLC method, the drug was resolved using a mobile phase phosphate buffer: acetonitrile (30:70%v/v) with pH adjusted to 3.5 using phosphoric acid on C18 column in isocratic mode. The retention time of trapidil was found to be 3.195 min.  In HPTLC method, the chromatograms were developed by using a mobile phase Methylene chloride: Methanol:  ammonia (8.5:1:0.5 v/v) on precoated plate of silica gel 60F254 and quantified by densiometric absorbance mode at 312nm. The Rf value of Trapidil was 0.28. In the UV method, trapidil was quantified at 221nm in acetronitrile. Recovery studies of 98.8-101.14%, percentage relative standard deviation (%RSD less than 2%) and correlation coefficient (linearity range) that developed methods were accurate and precise. These methods can be employed for the routine analysis of tablets containing trapidil.   Key words: Trapidil, RP-PHLC, HPTLC, UV spectrophotometry, validation

TrapidilRP-PHLCHPTLCUV spectrophotometryvalidation
5,096 views
1,602 downloads

Contributors:

 T.Sudha
,
 V. Vengadesh
,
 V.Ganesan
Research PaperID: AJPTR013031

TO EVALUATE ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF LEAF OF GYMNOSPORIA MONTANA- A NATIVE OF GUJARAT

Bhavita Dhru, Brijesh Patel, Lakshmi B, Maitreyi Zaveri

  Gymnosporia montana belonging to the family Celastraceae commonly known as Vikalo.  It is a shrub or tree growing wild in dry areas and is commonly found in Gujarat. It is widely used in treating sore, ulcer, gastro-intestinal disorders, toothache, and dysentery. The dried powder of leaf of Gymnosporia montana was subjected to the phytochemical screening for the presence of various phytoconstituents like alkaloids, flavonoids, saponins, tannins, anthraquinones, and carbohydrates, etc. Effectiveness of methanolic extracts of leaf of Gymnosporia montana was evaluated (100, 200 and 300 mg/kg; p.o.) against carrageenan-induced rat paw edema, and cotton pellet-induced chronic inflammation. Further, methanolic fraction of the plant was also evaluated (200 mg/kg; p.o.) in tail flick model using rats as well as acetic acid-induced writhing response using mice. Pretreatment with methanolic fraction showed significant (p

Gymnosporia montanaanti-inflammatoryVikalo
5,150 views
1,604 downloads

Contributors:

 Bhavita Dhru
,
 Brijesh Patel
,
 Lakshmi B
,
 Maitreyi Zaveri
Research PaperID: AJPTR013032

WOUND HEALING ACTIVITY OF DIFFERENT EXTRACT OF CALOTROPIS GIGANTEAN LINN

Mrunal K. Shirsat, Indrajeet J. Singhvi, Umesh.S. Pal

  In traditional medicine Calotropis gigantean Linn is a well-known plant in the traditional medicine of Rajasthan. Asclepiadaceae is used in folk medicine for pain, burns, eczema, skin diseases (Ring worm), Anti-bacterial and anti-fungal and wound-healing activities. Based on its traditional use, this plant was selected for evaluation of its wound healing potential. Preliminary wound healing activity was performed on different extracts and based on the findings; Petroleum ether, chloroform, methanol and distilled water extract was selected for further studies. The extract of Calotropis gigantean Linn promoted wound-healing activity significantly in all the three wound models studied. Topical application twice a day for 16 days significantly increased the wound contracting ability of the extract ointment (5% and 10%) and it was comparable to the reference standard nitrofurazone ointment in the excision wound model. The tensile strength in healing of incised wounds and dead space wound was found to be significantly higher in the group of animals treated with extract ointments (5% and 10%) and extracts (200mg/kg body weight) respectively. To investigate the effects of Calotropis gigantean Linn on wound healing activity in rats by excision, incision and dead space wound healing models in rats. Key words: Calotropis gigantean Linn, Excision wound model, Tensile strength Incised wounds, Dead space wound.

Calotropis gigantean LinnExcision wound modelTensile strength Incised woundsDead space wound.
5,411 views
1,690 downloads

Contributors:

 Mrunal K. Shirsat
,
 Indrajeet J. Singhvi
,
 Umesh.S. Pal
Research PaperID: AJPTR013033

PROSPECTIVE PROCESS VALIDATION OF GLICLAZIDE TABLET

Onkar J. Deshmukh, Swaroop R. Lahoti, Vivek B. Rajendra, Bhushan S. Gulecha, Pavan Kumar Rawat, Snehal A. kulkarni

  The objective of designing a dosage form is to achieve predictable therapeutic response to a drug included in a formulation which is capable of large scale manufacture with reproducible product quality. In order to ensure quality of product various features are required, like chemical and physical stability, preservation against microbial contamination, uniformity of dose of drug, acceptability to users including prescriber and patient, as well as suitable packing, labeling, and validation. The present research work focused on prospective process validation for the gliclazide 40mg tablet. Tablet was manufactured by wet granulation method. Formulation of tablet using Maize Starch, Avicel Ph 102, PVP-K30, sodium starch glycolate, Purified Talc, Aerosil 200 and  Magnesium stearate. Uniformity of dry mixing is excellent in 10min because % RSD found to be 0.4267-0.9021%. Granulating agent was prepared of desired consistency. Drying time 30 min is sufficient to achieve LOD 2-3%. Evaluation parameter of sizing shows effective LOD, % fine, BD & CI. Lubrication stage uniformity was achieved with 10min because % RSD found 0.8320-1.032% and flow properties was satisfactory. Compression machines optimum speed (20RPM) was satisfactory for effective compression. Based on results at each of the stages for the specified parameters it is concluded that gliclazide tablets can be effectively prepared with the desired specification & reproducible quality standards.  

Prospective ValidationGliclazideTablet.
5,452 views
1,698 downloads

Contributors:

 Onkar J. Deshmukh
,
 Swaroop R. Lahoti
,
 Vivek B. Rajendra
,
 Bhushan S. Gulecha
,
 Pavan Kumar Rawat
,
 Snehal A. kulkarni
Research PaperID: AJPTR013034

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET OF PIROXICAM

A. S. Panwar, V. Nagori, J. Chauhan, G. N. Darwhekar, D. K. Jain

  Piroxicam is a non-steroidal anti-inflammatory drug, classified in the Biopharmaceutics Drug Classification system as a Class II drug with low solubility and high permeability. It demonstrates a slow and gradual absorption via the oral route and has a long half-life of elimination, rendering a prolonged therapeutic action and a delayed onset of anti-inflammatory and analgesic effect. The basic objective of the present study is to formulate and evaluate the fast dissolving tablet of Piroxicam. Study proposes the use of a Sodium Satrch Glycolate (SSG) alone to prepare solid dispersion of piroxicam and comparison of its in-vitro dissolution with pure piroxicam. Fast Dissolving tablets can be prepared by conventional direct compression method using solid dispersion of superdisintegrants which shows rapid rate of disintegration. For better Hardness, less friability, faster wetting time and less moisture uptake combination of both MCC and Mannitol are required in the formulation.   Key Words: Fast dissolving tablet, Piroxicam, Sodium starch Glycolate (SSG)

Fast dissolving tabletPiroxicamSodium starch Glycolate (SSG)
5,702 views
1,732 downloads

Contributors:

 A. S. Panwar
,
 V. Nagori
,
 J. Chauhan
,
 G. N. Darwhekar
,
 D. K. Jain
Research PaperID: AJPTR013035

FORMULATION AND EVALUATION OF ENTERIC COATED TABLETS OF SODIUM VALPROATE

Alok Parkash, S.L. Kokhra, Bharat Parashar, Deepak Prashar

  In the present research paper, anticonvulsant Sodium valproate tablets were prepared using two different disintegrating agents in different ratio. Acrycoat-L-100 polymer was used as an enteric coating material. The tablets were formulated using direct compression method. Further post formulation parameters like hardness, friability, weight variations and content uniformity were studied. The results suggested, that the prepared enteric coated tablets specifics all the criteria of the standard formulation as per specified in monographs.  

Sodium valproateanticonvulsantpolymerenteric coated
5,768 views
1,667 downloads

Contributors:

 Alok Parkash
,
 S.L. Kokhra
,
 Bharat Parashar
,
 Deepak Prashar
Research PaperID: AJPTR013036

HPTLC FINGERPRINT PROFILE FOR QUANTITATIVE DETERMINATION OF VARIOUS PHYTOCONSTITUENTS IN ANISOMELES SPECIES

Yogesh V. Ushir, Krishnakant N. Patel, Navin R. Sheth

  In the present communication, finger print of two ethano-botanically important Anisomeles species has been developed. A sensitive and reliable densitometric High Performance Thin Layer Chromatography (HPTLC) method has been developed for the quantification of quercetin, β-sitosterol, stigmasterol, catechin and ovatodiolide present in Anisomeles indica and Anisomeles malabarica.  Chromatographic analysis was performed using methanol, chloroform, acetone and ethanol extract of these plants were developed in the different solvents such as toluene, chloroform, ethyl acetate, methanol at various proportions. Detection and quantification of all phytoconstituents was done by densitometric scanning at different wavelengths. These finger prints would be helpful in the standardization of these species.   Key words: HPTLC, Anisomeles indica, Anisomeles malabarica, phytoconstituents, standardization

HPTLCAnisomeles indicaAnisomeles malabaricaphytoconstituentsstandardization
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Contributors:

 Yogesh V. Ushir
,
 Krishnakant N. Patel
,
 Navin R. Sheth

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