mail
editor@ajptr.com
whatsapp
9409046853
logo

American Journal of PharmTech Research

LoginTrack

📢 Latest Update: New special issue call for papers on "Emerging Technologies in Research" - Submit by March 31, 2025

📢 Latest Update: New special issue call for papers on "Emerging Technologies in Research" - Submit by March 31, 2025

February 2026 Issue 1

Volume 16, Issue 1 - $2026Current Issue

Volume 16 Issue 1 Cover

Issue Details:

Volume 16 Issue 1
Published:Invalid Date

Editorial: February 2026 Issue 1

Welcome to the 2026 issue of American Journal of PharmTech Research. This issue showcases the remarkable breadth and depth of contemporary research across multiple disciplines. From cutting-edge applications of machine learning in climate science to the revolutionary potential of quantum computing in drug discovery, our featured articles demonstrate the power of interdisciplinary collaboration in addressing global challenges.

We are particularly excited to present research that bridges traditional academic boundaries, reflecting our journal's commitment to fostering innovation through cross-disciplinary dialogue. The integration of artificial intelligence with environmental science, the application of blockchain technology to supply chain management, and the convergence of urban planning with smart city technologies exemplify the transformative potential of collaborative research.

As we continue to navigate an era of rapid technological advancement and global challenges, the research presented in this issue offers both insights and solutions that will shape our future. We thank our authors, reviewers, and editorial board members for their continued dedication to advancing knowledge and promoting scientific excellence.

Dr Hemangi J Patel
Editor-in-Chief
American Journal of PharmTech Research

Articles in This Issue

Showing 6 of 6 articles
Research PaperID: AJPTR161001

Gastroretentive Drug Delivery Systems: A Comprehensive Review on Floating Tablet Technology

Alina Bashir Kadvekar, Niranjan Dattatray Chivate, Shivanjali Gopal Devkar

Gastroretentive drug delivery systems (GRDDS) have emerged as an advanced approach to overcome the limitations of conventional oral dosage forms by prolonging gastric residence time and improving drug bioavailability. The objective of these systems is to remain buoyant in gastric fluid for extended periods, allowing controlled release of drugs and enhanced absorption of medications with limited absorption windows. Floating tablets achieve buoyancy using low-density excipients, such as gas-generating substances like sodium bicarbonate, or swellable polymers like hydroxypropyl methylcellulose (HPMC). Formulation strategies generally employ polymeric matrices, effervescent components, or coating technologies to regulate release kinetics and enhance stability. Evaluation parameters, such as floating lag time, total floating duration, and in vitro and in vivo correlation, are essential for assessing system performance. GRDDS can improve the therapeutic efficacy of medicines used in gastrointestinal disorders and those requiring localized gastric delivery. Despite significant advancements, variability in gastric motility and physiological factors limit the reproducibility and scalability of formulations. This review consolidates current progress and identifies future directions for optimized gastroretentive floating tablet technology.

Gastroretentive drug delivery systemFloating tabletBuoyancybioavailabilityPolymerSustained release+1 more
351,826 views
105,691 downloads

Contributors:

 Alina Bashir Kadvekar
,
 Niranjan Dattatray Chivate
,
 Shivanjali Gopal Devkar
Research PaperID: AJPTR161002

A Detailed Review on Novel Solubility Enhancement Techniques

R. Sailaja, B.Meghana, K.Supriya, M.Chandrika, Sh.Soubhia, S.Naidu

Approximately 40% of the marketed drugs and 70 to 90% of the drugs in development are poorly water soluble. Solubility plays a crucial role in the absorption of the drugs ingested orally. As most of the drugs are poorly soluble the solubility enhancement is the prime requisite to enhance dissolution, bioavailability and therapeutic efficacy. Several approaches as physical modification, pH adjustment, Super critical fluid technology, liquisolid techniques and chemical modifications are to enhance the solubility. Physical methods include particle size reduction, solubility enhancement by carriers, by surfactants, by complexation chemical modifications include Hydrotrophy, co-solvency, nano technology, salt formation and co-crystallization. This review mainly focuses on novel techniques to enhance solubility includes liquisolid system, Spherical agglomeration, melt sonocrystallization, Hydrotrophy, Natural deep eutectic solvents nano technology-based methods, solid state engineering, advanced formulation strategies include self-emulsifying drug delivery systems, and supercritical fluid technology and other innovative techniques like and micro wave assisted techniques.

Solubility EnhancementHydrotrophyCo-solvencyNano technology
352,117 views
105,653 downloads

Contributors:

 R. Sailaja
,
 B.Meghana
,
 K.Supriya
,
 M.Chandrika
,
 Sh.Soubhia
,
 S.Naidu
Research PaperID: AJPTR161003

Microwave-Assisted Green Synthesis and Anticancer Activity of Gold and Silver Nanoparticles Using Root Extract of Hymenodictyon Orixense (Roxb.)

Riya Sahu, Vinod D. Rangari

This study reports the eco-friendly synthesis of gold (AuNPs) and silver (AgNPs) nanoparticles using the alcoholic root extract of Hymenodictyon orixense. The use of H. orixense root extract offers a novel approach in green synthesis, as it has been relatively underexplored.The nanoparticles were synthesized via a microwave-assisted method, utilizing extract of H. orixense as a reducing and stabilizing agent. The phytochemicals present in the extract played a crucial role in reducing the metal ions and stabilizing the resulting nanoparticles. The synthesis was confirmed by a visual colour change and characterized using various physicochemical techniques. The synthesized gold and silver nanoparticles showed characteristic surface plasmon resonance peak at 544 nm and 427 nm, respectively. They exhibited significant cytotoxicity against MCF-7 (breast cancer), A549 (lung cancer), and HepG2 (liver cancer) cell lines, with AuNPs exhibiting slightly higher cytotoxicity compared to AgNPs. Statistical analysis using ANOVA revealed that the cytotoxic effects of both AuNPs and AgNPs were significant (p < 0.001) compared to the untreated control cells. The study demonstrates the potential of H. orixense-mediated green synthesis in producing nanoparticles with promising anticancer properties. Quantitative comparisons revealed that AuNPs had lower IC50 values and higher antioxidant activity than extract and AgNPs. The significant cytotoxicity exhibited by these nanoparticles suggests their potential for further development as therapeutic agents. However, further studies are needed to elucidate the underlying mechanisms, optimize the synthesis process, and evaluate the in vivo efficacy and safety of these nanoparticles.

Hymenodictyon orixenseroot extractgold nanoparticlesilver nanoparticlemicrowave-assisted green synthesisanticancer activity.
352,248 views
105,669 downloads

Contributors:

 Riya Sahu
,
 Vinod D. Rangari
Research PaperID: AJPTR161004

From Seeds to Sheild: Design and Evaluation of Herbal Nail Lacquer- A Natural Antifungal Approach Against Onychomycosis

Smt. Aishwarya Hiremath1* Samarth AV, Atiya, Shrushti S, Manikantha P Garlpet, Muhammed Mussamil A

Onychomycosis also referred to as dermatophytic onychomycosis or Tinea unguium, is a fungal nail infection primarily caused by dermatophytes (like Trichophyton rubrum), yeasts (like Candida albicans), and non-dermatophytic moulds. In this study, an effort was made to develop a herbal medicated antifungal nail lacquer using Caesalpinia bonducella seeds. The objective was to enhance clinical efficacy while improving patient compliance. Authenticated C. bonducella seeds were extracted and formulated into nail lacquers using suitable excipients, including film-forming agents, plasticizers, solvents, penetration enhancers, and resins. The prepared formulations were evaluated for various physicochemical and biological parameters such as smoothness, glossiness, non-volatile content, drug content, adhesion, diffusion, and antifungal activity (zone of inhibition). FTIR analysis confirmed drug–excipient compatibility by retaining characteristic peaks. Among the formulations, F5 was identified as the optimized batch and subjected to accelerated stability testing under ICH guidelines at 37 ± 2 °C for one month. The results showed no significant changes in its initial characteristics, while the formulation maintained excellent antifungal activity. Overall, the developed antifungal nail lacquer demonstrated safety, stability, and effectiveness, suggesting its potential as a novel dosage form for the treatment of dermatophytic nail infections such as onychomycosis. Its use may significantly improve therapeutic outcomes and patient adherence compared to conventional therapies.

OnychomycosisAntifungal nail lacquerCaesalpinia bonducellaDermatophytesDiffusion studiesFTIR
352,323 views
105,654 downloads
DOI:
https://doi.org/10.5281/zenodo.18666918

Contributors:

 Smt. Aishwarya Hiremath1* Samarth AV
,
 Atiya
,
 Shrushti S
,
 Manikantha P Garlpet
,
 Muhammed Mussamil A
Research PaperID: AJPTR161005

A Comparative Study for Method Development and Validation of Daprodustat in Bulk and Pharmaceutical Tablet Dosage Form by UV-visible and RP-HPLC.

Vijaykumar Tirlapurkar, Ashwini Rayaji

This research introduces a straightforward, rapid, sensitive, and selective analytical method for measuring daprodustat in both bulk powder and tablet forms. The techniques used include UV-Visible spectrophotometry and reversed-phase high-performance liquid chromatography (RP-HPLC). For the UV-Visible method, a Systonic AU-2702 double-beam spectrophotometer was used to measure Daprodustat 's absorbance at 265 nm. The RP-HPLC procedure employed a Shimadzu SPD-10A C18 column (250×4.6 mm, 5 µm). The mobile phase consisted of a mixture of acetonitrile and distilled water (70:30, v/v), with 0.1% formic acid added. Key operational parameters included a flow rate of 1.2 mL/min, an injection volume of 10 μL, and a column temperature of 30 °C. The method's linearity ranged from 10 to 100 μg/mL. The entire procedure was validated following ICH Q2 (R1) guidelines, confirming its specificity, linearity, sensitivity, precision, accuracy, robustness, and system suitability. The technique yields highly sensitive results, with Limits of Detection (LODs) and Limit of Quantification (LOQs) of 0.6174 μg/mL and 1.87μg/mL for daprodustat. Recovery rates ranged from 98% to 102%, and both intra-day and inter-day precision (measured by % RSD) were below 2%. The method demonstrated excellent specificity, avoiding interference from excipients or formulation matrices. Overall, this study provides a complete analytical framework applicable for routine pharmaceutical analysis, ensuring quality control, safety assessment, and regulatory compliance for daprodustat.   

DaprodustatUV VIS SpectrophotometerRP-HPLCMobile phaseStationary PhaseC-18 Column+4 more
352,632 views
105,749 downloads

Contributors:

 Vijaykumar Tirlapurkar
,
 Ashwini Rayaji
Research PaperID: AJPTR161006

Human Breast Milk as a Living Therapeutic System: Translational Implications for Neonatal Health

Bharathi Bhogenahalli Venkatappa, Muchukota Sushma, Sneha G, Chandana BS, Aiswarya S

The use of human breast milk is gaining new recognition as more than just nutrition and as a multifaceted, dynamic, and biologically active environment with essential treatment effects in neonatal health. In addition to macronutrients, it has a variety of bioactive factors such as immunoglobulins, human milk oligosaccharides, antimicrobial peptides, cytokines, growth factors, microbiota, extra-cellular vesicles and microRNAs which, in combination, promote immune maturation, gut and brain development, metabolic programming and defense against infectious diseases and inflammatory diseases. This review summarizes the existing literature which conceives breast milk as a living therapeutic system with high level of translational application to the care of the neonatal population. We discuss mechanistic pathways by which breast milk has an impact on immune regulation, gut-microbiome interactions, neurodevelopment and long-term disease risk reduction, which are necrotizing enterocolitis, sepsis, allergic conditions, and metabolic disorders. New translational evidence that reveals the effects of breast milk-derived bioactive as natural immunomodulators, postbiotics, and epigenetic regulators is mentioned. The review also discusses clinical implications of vulnerable groups like preterm and low-birth-weight babies, as well as the issue of breast milk use, formula supplementation, and inequity in breastfeeding. This review brings together molecular biology, clinical neonatology, and translational nutrition science and emphasizes the importance of breast milk as a platform of early-life precision health and as a paradigm of the next generation of nutrition and therapeutic approaches.

Human breast milkneonatal healthimmune programmingmicrobiometranslational nutritionbioactive milk components.
352,421 views
105,849 downloads

Contributors:

 Bharathi Bhogenahalli Venkatappa
,
 Muchukota Sushma
,
 Sneha G
,
 Chandana BS
,
 Aiswarya S

Related Issues

Volume 15, Issue 6

2025 • 17 articles

Volume 15, Issue 5

2025 • 15 articles

Volume 15, Issue 4

2025 • 10 articles

Volume 15, Issue 3

2025 • 8 articles

Whatsapp