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American Journal of PharmTech Research

📢 Latest Update: New special issue call for papers on "Emerging Technologies in Research" - Submit by March 31, 2025

📢 Latest Update: New special issue call for papers on "Emerging Technologies in Research" - Submit by March 31, 2025

June 2025 Issue 3

Volume 15, Issue 3 - $2025

Volume 15 Issue 3 Cover

Issue Details:

Volume 15 Issue 3
Published:Invalid Date

Editorial: June 2025 Issue 3

Welcome to the 2025 issue of American Journal of PharmTech Research. This issue showcases the remarkable breadth and depth of contemporary research across multiple disciplines. From cutting-edge applications of machine learning in climate science to the revolutionary potential of quantum computing in drug discovery, our featured articles demonstrate the power of interdisciplinary collaboration in addressing global challenges.

We are particularly excited to present research that bridges traditional academic boundaries, reflecting our journal's commitment to fostering innovation through cross-disciplinary dialogue. The integration of artificial intelligence with environmental science, the application of blockchain technology to supply chain management, and the convergence of urban planning with smart city technologies exemplify the transformative potential of collaborative research.

As we continue to navigate an era of rapid technological advancement and global challenges, the research presented in this issue offers both insights and solutions that will shape our future. We thank our authors, reviewers, and editorial board members for their continued dedication to advancing knowledge and promoting scientific excellence.

Dr Hemangi J Patel
Editor-in-Chief
American Journal of PharmTech Research

Articles in This Issue

Showing 8 of 8 articles
Research PaperID: AJPTR153001

Reproductive cycle of the critically threatened Cyprinid fish Puntius vittatus

J. Michael Antony Prabhu Arachi

The females were significantly bigger than males at all seasons of the year, and there was a preponderance of females only in spawning months; otherwise, both sexes were found in almost equal numbers. The males matured at a smaller size, 2.5cm SL, than the females, 3.1-3.5 cm SL. The size of the largest mature male was 3.25cm in total length and 2.65 grams in live weight, and that of the largest mature female was 5.22cm in total length and 3 grams in live weight. The maximum GSI of a mature female fish during the spawning season was 3.5%, and that of a mature male was 3.4. The highest value of condition factor of a mature female was 2.9, and that of 0a mature male was 2.6 during the breeding month. The analyses of all these reproductive traits of P.vittatus pinpoint the exact spawning season of the fish and also its reproductive capacity to enable one to employ this species in fish farming practice.

Puntius vittatusreproductive cycleGonadosomatic index
346,009 views
103,847 downloads

Contributors:

 J. Michael Antony Prabhu Arachi
Research PaperID: AJPTR153002

A Short Duration Study Of Febuxostat- The Clinical Improvement, Side Effects and Serum Uric Acid Levels In Gouty Arthritis Patients - A Prospective Study

Ravi Prakash Degala, N.Suvarna Jyothi, L.Chandrika, M.S.S.S.S.Kalyani, G.Anupama3 D.Jenny

Febuxostat is a novel, potent, non-purine selective xanthine oxidase inhibitor, which in clinical trials demonstrated superior ability to lower and maintain serum urate levels below 5 mg/dL compared with conventionally used doses of allopurinol. Febuxostat was well tolerated in long term treatment in patients with hyperuricemia including those experiencing hypersensitity/intolerance to allopurinol. Dose adjustment appears unnecessary in patients with mild to moderate renal or liver insufficiency or advanced age. The most common adverse reactions reported were abnormal liver function tests, headache, and gastrointestinal symptoms, which were usually mild and transient. However, whether hepatotoxicity becomes a limitation in the use of febuxostat needs to be determined in further studies. An increased frequency of gout flares occurs for a prolonged period after treatment initiation, as with any aggressive lowering of serum urate, and prolonged prophylaxis with colchicine or NSAIDs is usually required. Febuxostat has been granted marketing authorization by the European Commission in early 2008 for the treatment of chronic hyperuricemia and gout. Febuxostat is the first major treatment alternative for gout in more than 40 years and is a promising alternative to allopurinol, although continued long-term surveillance on safety and efficacy is required.

Short duration studyFebuxostatclinical improvementsserum acid levelsgouty arthritis patients.
345,871 views
103,742 downloads

Contributors:

 Ravi Prakash Degala
,
 N.Suvarna Jyothi
,
 L.Chandrika
,
 M.S.S.S.S.Kalyani
,
 G.Anupama3 D.Jenny
Research PaperID: AJPTR153003

A Comprehensive Review On Synthetic Routes and Pharmacological Activities of Pyrazoles and Quinolines

Sonal Bansal, Mahendra Singh Ranawat

In the modern world, a number of heterocycles have emerged and are showing important roles in a variety of human-beneficial pharmaceutical compounds. Pyrazoles are nitrogen-containing heterocyclic compounds with five members. They have garnered a lot of attention because they belong to a significant class of chemicals for therapeutic development and Quinolines, A typical example of bicyclic heterocyclic compounds. Meanwhile, derivatives of pyrazole and quinoline have been synthesized as target structures and have shown a wide range of biological actions, including antitubercular, anticancer, antifungal, anti-inflammatory, antibacterial, and anti-tuberculosis properties. The findings of published studies on the synthesis and biological activity of quinoline and pyrazole derivatives are compiled in this review. The Scopus database was consulted to gather and evaluate the published research papers on the biological activities and synthesis of pyrazole and quinoline derivatives that were published between January 2019 and December 2023.

Heterocyclespyrazolesquinolineanticanceranti-inflammatoryresearch papers.
345,974 views
103,928 downloads

Contributors:

 Sonal Bansal
,
 Mahendra Singh Ranawat
Research PaperID: AJPTR153004

Comprehensive Review On Dry Powder Inhalations: Mechanisms, Technologies, and Future Directions

Chinna Reddy Palem, Venkatasanthosh Paidi, Deepthi Battula, Sricharan Gumudevelli

Dry powder inhalers (DPIs) represent a pivotal technology in pulmonary drug delivery, offering advantages such as improved stability, breath-actuated dosing, and enhanced patient convenience. This review presents an in-depth exploration of DPIs, from foundational principles to emerging innovations. Beginning with the historical development and physiological basis for pulmonary delivery, the review delves into the mechanisms of DPI function, highlighting the importance of aerodynamic particle behavior and key physicochemical properties. Critical formulation components such as active pharmaceutical ingredients, carrier particles, and excipients are examined alongside particle engineering and manufacturing technologies essential for scalable, high-quality production. Device design and aerosolization mechanisms are discussed in the context of usability, patient handling, and dose consistency. In vitro and in vivo performance evaluation techniques, including aerosol characterization, deposition studies, and pharmacokinetics, are reviewed. This review also captures recent advances in nanotechnology, biologics delivery, smart inhalers, and vaccine formulations. Regulatory frameworks, market dynamics, and current commercial DPI products are assessed to provide a comprehensive view of the global landscape. Finally, future directions are outlined, including personalized medicine approaches, sustainable inhaler technologies, and opportunities for innovation in systemic and respiratory therapies.

Dry powder inhalersPulmonary drug deliveryRegulatory Guidelinesfuture perspectives
346,202 views
103,846 downloads

Contributors:

 Chinna Reddy Palem
,
 Venkatasanthosh Paidi
,
 Deepthi Battula
,
 Sricharan Gumudevelli
Research PaperID: AJPTR153005

Perception of General Public on Antibiotic Resistances- A Survey Study

Mahesh B Narkhede, Rani J Rajput, Puja V Patil, Vaibhav S Adhao, Raju R Thenge, Pavan P Chinchole

To evaluate the general public's awareness, knowledge, attitude, and behavior about the use of antibiotics and the emergence of antibiotic resistance. From January to April 2025, A study using a cross-sectional survey standardized question was given to the participants.  To gather information from 205 respondents, a questionnaire was created. In order to gather information on sociodemographic traits, antibiotic use, antibiotic knowledge, and antibiotic resistance, the survey was divided into three components. A total 205 participated in this study, 52.7% were male and 46.3% were female successfully answered every question, demonstrating a 99% response rate.  118 participants, or 57.6% of the sample, agreed with that the use of antibiotics was a significant and grave public health concern in your community. And the 39 (19%) patient ware not aware about antibiotic resistance is a growing concern in your community. The result of study show that patient and public aware to use of antibiotic and antibiotic resistance. The present study discovered that a high proportion of participants unaware being of "Antibiotic resistance and its risk to public health". To change their attitudes about the use of antibiotics and their knowledge and views of antibiotic resistance, more educational programs are required.  Overall, the study participants had an extensive knowledge of antibiotic resistance.

Antibiotic ResistanceAntibiotic UsagePublic PerceptionKnowledgeAwareness
346,338 views
103,973 downloads

Contributors:

 Mahesh B Narkhede
,
 Rani J Rajput
,
 Puja V Patil
,
 Vaibhav S Adhao
,
 Raju R Thenge
,
 Pavan P Chinchole
Research PaperID: AJPTR153006

Development and Comprehensive Validation of A Stability-Indicating UPLC Method For the Simultaneous Estimation of Sulfamethoxazole and Clindamycin In Combined Pharmaceutical Dosage Form

Isteyaq Shareef, Kumaraswamy Gandla

To develop and validate a rapid, precise, and stability-indicating UPLC method for the simultaneous estimation of Sulfamethoxazole and Clindamycin in combined pharmaceutical dosage form, in accordance with ICH Q2 (R1) guidelines 5. A simple, precise, and robust UPLC method was developed and validated for the simultaneous estimation of Sulfamethoxazole and Clindamycin in a fixed-dose pharmaceutical formulation 1–3. The method was developed on a reverse-phase C18 column using a mobile phase of methanol and water. Detection was carried out at 254?nm. Validation followed ICH Q2 (R1) guidelines, including accuracy, precision, linearity, robustness, ruggedness, and sensitivity 4–6. Linearity was observed over the range of 10–200 μg/mL for both drugs (R² > 0.998). %Recovery was within 98–102% with % RSD < 0.5%. LOD and LOQ were 0.195 μg/mL and 0.592 μg/mL, respectively. The method was unaffected by small deliberate changes in analytical conditions. The validated method is stability-indicating, highly sensitive, and suitable for routine analysis and quality control of Sulfamethoxazole and Clindamycin in combined dosage form.

SulfamethoxazoleClindamycinUPLCMethod ValidationICH Q2(R1)Stability-Indicating
346,712 views
104,047 downloads

Contributors:

 Isteyaq Shareef
,
 Kumaraswamy Gandla
Research PaperID: AJPTR153007

Formulation and Evaluation of Self-Emulsifying Drug Delivery System Of Methotrexate

Ashvitha Kumari, Smitha Shetty

The objective of this study was to prepare the self-emulsifying drug delivery system of methotrexate for oral use. Preparation composed of soybean oil as oil phase, Span 80 as surfactants, isopropyl alcohol as co-surfactant, 0.1 N NaOH as the aqueous phase. Methotrexate is given orally in treatment of cancer and rheumatoid arthritis. The Anti-neoplastic drug MTX is having less aqueous solubility (50-60 %) and bioavailability of 60-70 %. Hence the present study is aimed to formulate and evaluate solid self-nano emulsifying drug delivery system with the aim of increasing the solubility and bioavailability which will decrease the dosing frequency in turn increase patient compliance. Liquid SNEDDS was prepared by adding drug to oil, surfactant and co-surfactant and heated up to at 60 ºC under continuous stirring until a clear solution is formed. All the formulations were optimized to get the best solubility results for MTX. Solid SNEDDS was prepared by mixing liquid SNEDDS with MCC in 1:1 proportion. The formulations were evaluated for angle of repose, bulk density, zeta potential, IR spectroscopy, in vitro dissolution, average particle size, size distribution and stability studies. The average particle size of the liquid SNEDDS was 60.4 nm and solid SNEDDS was 60.4nm. The surface charge was confirmed by the measurement of the zeta potential for the liquid SNEDDS and it was found to be -22.4 mV and that of the solid SNEDDS was -22.4 mV. The PDI value remained approximately around 0.565 indicated that all the nano particles were uniformly dispersed in the emulsion.

Methotrexatesoyabean oilspan 80solid self nano emulsifying drug delivery systemAntineoplasticPseudoternary phase
346,422 views
103,986 downloads

Contributors:

 Ashvitha Kumari
,
 Smitha Shetty
Research PaperID: AJPTR153008

Formulation and Evaluation of Anti-Ageing Cream From Centella Asiatica, Benincasa Hispida and Punica Granatum

M. Shamshath Begum, N. Deepa, V. Nivetha, V.Pavithra, B. Praveen, V. Preetha, D. Priyadharshini

Skin aging is a natural process influenced by intrinsic and extrinsic factors, leading to wrinkles, dryness, and reduced elasticity. This study aims to formulate and evaluate an anti-aging cream using natural extracts of Centellaasiatica, Benincasahispida, and Punicagranatum, which are rich in flavonoids, tannins, glycosides, and antioxidants. These phytoconstituents possess anti-aging, anti-inflammatory, and emollient properties. A single cream formulation was prepared using juicy and pulpy extracts of the three plants in equal proportions. The cream was evaluated for physical appearance, viscosity, spreadability, and skin irritation. Results showed that the formulation was homogenous, stable, and exhibited good spreadability and permeability. No signs of erythema or edema were observed in the skin irritation test, confirming the formulation's safety and non-toxic nature. The combination of extracts showed enhanced anti-aging effects compared to individual plant extracts, demonstrating synergistic activity. The use of topical delivery for this formulation also ensures better patient compliance and targeted action. In conclusion, the developed herbal anti-aging cream is effective, safe and offers a promising natural approach to managing skin aging.

Anti-ageingTopical formulationCentellaasiaticaBenincasahispidaPunicagranatum.
346,643 views
104,123 downloads

Contributors:

 M. Shamshath Begum
,
 N. Deepa
,
 V. Nivetha
,
 V.Pavithra
,
 B. Praveen
,
 V. Preetha
,
 D. Priyadharshini
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