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American Journal of PharmTech Research

📢 Latest Update: New special issue call for papers on "Emerging Technologies in Research" - Submit by March 31, 2025

📢 Latest Update: New special issue call for papers on "Emerging Technologies in Research" - Submit by March 31, 2025

August 2023 Issue 4

Volume 13, Issue 4 - $2023

Volume 13 Issue 4 Cover

Issue Details:

Volume 13 Issue 4
Published:Invalid Date

Editorial: August 2023 Issue 4

Welcome to the 2023 issue of American Journal of PharmTech Research. This issue showcases the remarkable breadth and depth of contemporary research across multiple disciplines. From cutting-edge applications of machine learning in climate science to the revolutionary potential of quantum computing in drug discovery, our featured articles demonstrate the power of interdisciplinary collaboration in addressing global challenges.

We are particularly excited to present research that bridges traditional academic boundaries, reflecting our journal's commitment to fostering innovation through cross-disciplinary dialogue. The integration of artificial intelligence with environmental science, the application of blockchain technology to supply chain management, and the convergence of urban planning with smart city technologies exemplify the transformative potential of collaborative research.

As we continue to navigate an era of rapid technological advancement and global challenges, the research presented in this issue offers both insights and solutions that will shape our future. We thank our authors, reviewers, and editorial board members for their continued dedication to advancing knowledge and promoting scientific excellence.

Dr Hemangi J Patel
Editor-in-Chief
American Journal of PharmTech Research

Articles in This Issue

Showing 7 of 7 articles
Research PaperID: AJPTR134001

Quality Control in Mammography; An Assessment of System's Performance of 3D Breast Tomosynthesis

Mohammed A. Alnafea, Reem M. Alharbi

Breast tomosynthesis has become a well-established imaging technique for clinical assessment of breast cancer. This Tree-Dimensions (3D) imaging technique is one of a major recently used method for early breast cancer detection particularly for women with a dense breast. It can also aid in the clarifying of a breast cancer diagnosis, whether by initial screening or following up after a suspicious area in the breast has been found. The image of such technique must have an optimal contrast to display mass densities and speculated fibrous structures, in order to diagnose breast cancer accurately at the earliest feasible stage. Furthermore, the spatial resolution must be sufficient to reveal the size and form of micro calcifications. To improve the accuracy of imaging diagnosis system, an effective Quality Control (QC) program can be implemented to optimize the accurate diagnosis of mammographic imaging. The main aim of this study is to evaluate the QC of 3D Tomosynthesis system, including Kilo voltages peak (kVp) accuracy, mAs linearity, Half Value Layer (HVL), Automatic Exposure Control (AEC), radiation output and mean glandular dose (MGD). Image quality assessment also included to check of spatial resolution, Signal to Noise Ratio (SNR) and Contrast to Noise Ratio (CNR). Accreditation phantoms have been used during the study. This study reveals that international standard guidelines which contain basic requirements for QC are obtained.

3DTomosynthesisX-ray MammographyQCMGDHVL.
335,801 views
100,771 downloads

Contributors:

 Mohammed A. Alnafea
,
 Reem M. Alharbi
Research PaperID: AJPTR134002

A Study on the Antimicrobial Activities of Hot Spring Bakreshwar Water on Multiple Drug Resistant Bacteria

Disha Roy, Bhaskar Narayan Chaudhuri, Partha Guchhait, Satadal Das

Bakreshwar hot springs have geological significance, and are known to have curative properties for any diseases. In this study, antimicrobial activities of the hot spring Bakreshwar water were assessed against MDR and ATCC microorganisms. A range of bacterial strains, including Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), Escherichia coli (MDR), Klebsiella sp. (MDR), Acinetobacter sp. (MDR) and Pseudomonas sp. (MDR) were used to evaluate the antimicrobial activity of the water. The results showed that the hot spring water expressed significant antimicrobial activity against all tested MDR and ATCC microorganisms. High temperature and strong alkaline pH (9.2) of the hot spring water, the presence of minerals and the physical and chemical agents in the water are probably responsible for the antimicrobial activities that were observed. The findings lead us to believe that the hot spring water from Bakreshwar might be a source of natural antimicrobial properties, which could be utilized for the development of new drugs for treating infections caused by resistant bacteria. Further studies are required to confirm the specific mineral, chemical or physical agent that are responsible for the observed activity.

Bakreshwar’s hot spring waterantimicrobial activityStaphylococcus aureusEscherichia coliEscherichia coli (MDR)Klebsiella sp.+2 more
335,584 views
100,699 downloads

Contributors:

 Disha Roy
,
 Bhaskar Narayan Chaudhuri
,
 Partha Guchhait
,
 Satadal Das
Research PaperID: AJPTR134003

A Prospective study of Post Operative Orthopedic Patients on Assessing Health related Quality of life and the Factors Affecting their HRQOL with Counselling.

Ayyanki Anisha, K. Naga Sai Mounika, Jabeen Jaha, A. Manasa Goud, Kashif Ur Rahman, A.W, Mostafizur Rahman, Sahinoor Hassan

Orthopedic is a branch of medicine dealing with the correction of deformities of bones or muscles. This research study aims to investigate the Health-Related Quality of Life (HRQOL) of Post-operative orthopedic patients and explore the factors that influence their HRQOL using WHO-BREF questionnaire, and by supplement counselling to address patient’s psychosocial needs and enhance their HRQOL. This study involved a sample of orthopedic patients who undergone various surgical procedures and were recruited from tertiary care hospital. The data was collected through interviews using WHO-BREF Questionnaire and analyzed using appropriate Statistical techniques. The findings contribute to a comprehensive understanding of the factors influencing the HRQOL of post-operative orthopedic patients, thereby highlighting the importance of incorporating counseling as a supportive measure in their care. Ultimately leading to enhanced patient outcomes and overall satisfaction. The P-value was found to be appropriate.

Health related quality of lifePost-operative orthopedic patientsWHO-BREFCounselingpsychosocial factorsP- Value+1 more
335,955 views
100,840 downloads

Contributors:

 Ayyanki Anisha
,
 K. Naga Sai Mounika
,
 Jabeen Jaha
,
 A. Manasa Goud
,
 Kashif Ur Rahman
,
 A.W
,
 Mostafizur Rahman
,
 Sahinoor Hassan
Research PaperID: AJPTR134004

Quality Control measurements for general X-Ray machine through X-ray meter

Mohammed A. Alnafea, Huda H. Mujammami

The aim of a quality assurance (QA) program is to assist a radio-diagnostic machine to obtaining adequate radiological quality information with a minimum of dose to the subject. An integrated part of a quality assurance program is Quality Control (QC) ascertaining quality by measurements and other procedures. QC in diagnostic radiography begins with production of predictable exposures. In this study the four tests (reproducibility, accuracy of kV, half value layer (HVL) and mAs linearity) were determined by Piranha X ray meter and were carried out f­or General X-Ray machine at Olaya Medical Complex. The QC tests have been carried out according to the intentional standard reports (AAPM No. 74) and National recommendations of King Abdullah City for Atomic & Renewable Energy. Various safety measures are taken by considering work personnel's safety. Thus, some QC tests were determined using the X-ray meter. For the accomplishment of this study, the tests of tube voltage accuracy and reproducibility, HVL and effective energy, air Kerma and air Kerma rate were performed, with their associated errors calculated. The obtained results were in the acceptable limits. The survey revealed that the QC program was conducted to this X-ray machine at regular intervals. Thus the calibration accuracy results Confirm that, the X-Ray E Machine Result is Pass.

Quality AssuranceQuality ControlX-Ray MachineX-ray meter
336,006 views
100,778 downloads

Contributors:

 Mohammed A. Alnafea
,
 Huda H. Mujammami
Research PaperID: AJPTR134005

Preservatives -A Masked Health Attacker and Aggresion In Human Life Span

Siva Kumar B

Preservatives extend the shelf life of food, cosmetics and pharmaceutical products by preventing their deterioration. Antimicrobials such as nitrites, nitrates, benzoates and sulfur dioxide destroy or retard the growth of bacteria, yeasts and moulds. Antioxidants such as butylated hydroxytoluene (BHT), Butylated hydroxyanisole (BHA) and propyl gallate slow or stop the decomposition of fats and oils. Anti-enzyme preservatives such as citrus and Erythorbic acids block enzymatic processes such as maturation that occur in food even after harvest. Natural substances such as salt, sugar, vinegar and Spices have been used as preservatives since time immemorial. The majority of the preservatives used today are artificial rather than natural. Several of them are toxic and several others have life-threatening side effects. Researchers have reported that artificial preservatives such as nitrates, Benzoates, sulfites, sorbates, parabens, formaldehyde, BHT, BHA and miscellaneous others can lead to serious health risks such as hypersensitivity, allergies, asthma, hyperactivity, neurological damage and cancer. Studies have shown that various natural preservatives obtained from plants, animals, microbes and the minerals contain antioxidant, antimicrobial and anti-enzymatic properties Basil, clove, neem and rosemary extracts are promising alternatives to their artificial counterparts. This article aims to raise awareness of the harmful effects of artificial preservatives and recommends the use of preservatives for better therapeutic efficacy, safety and preservation of substances with better overall health

Preservativeslife spannitratesBHABHTSorbates.
336,204 views
100,835 downloads

Contributors:

 Siva Kumar B
Research PaperID: AJPTR134006

Evaluation of Larvicidal Activity of Methanolic Extract of Citrullus Lanatus

Dhanapal Venkatachalam

The present study was performed with the objectives of elaborating the larvicidal efficacy of Methanolic extract of Citrullus lanatus (MECL) leaves against Anopheles stephensi, Culex quinquefasciatus and Aedes aegypti. It has been reported used widely in traditional herbal medicine. The leaves of Citrullus lanatus is analgesic, anti-inflammatory, mosquitocidal,    gonorrhea and anti-microbial property. The larvicidal activity of plant extract was carried out on late 3rd and early 4th instar larvae of Anopheles stephensi, a primary vector of urban malaria, Culex quinquefaciatus, a common vector of filariasis, Aedes aegypti, common vector of dengue and yellow fever. LC50 and LC90 of MECL were determined against Anopheles stephensi, Culex quinquefasciatus and Aedes aegypti by using Abbott’s formula. LC50 and LC 90 of MECL against Anopheles stephensi were found to be 84.23ppm & 989.396ppm. LC50 and LC90 of MECL against Culex quinquefasciatus were found to be 51.31ppm &405.88ppm. The LC50 was found to be 2645ppm or 2.645%v/v for Aedes agypti. The LC90 value was found to be 138326ppm or 138.326%v/v for Aedes agypti The results of the present study suggest that methanolic extract of Citrullus lanatus showed promising larvicidal activity against important vectors of malaria, filarial, dengue, dengue haemorrhagic fever, yellow fever, chikungunya.

Larvicidal activityCitrullus lanatusAnopheles stephensiCulex quinquefasciatus Aedes aegypti
336,214 views
100,888 downloads

Contributors:

 Dhanapal Venkatachalam
Research PaperID: AJPTR134007

Evaluation of Nutritional and Mineral Composition of Morning glory leaves

Ruchika Garg, Naresh Kalra

Rivea hypocrateriformis (Desr.) Choisy, a member of the Convolvulaceae family and commonly known as 'Morning Glory,' is a woody climbing shrub widely employed in Ayurvedic medicine.  In traditional medicine, various parts of this plant, including its bark, stems, and leaves, have been employed to address a range of health concerns, such as malaria, cancer, mental disorders, and pain relief. In spite of its numerous medicinal attributes, no published work is available till date on nutritional values and elemental analysis of leaves. The nutrient and antinutrient compositions of the leaves were investigated . The result of proximate analysis shows that crude lipid, crude fibre, crude protein, and carbohydrate in the leaves were 2.33 ± 0.51%, 21.34 ± 0.17 %, 11.32 ± 0.22 and 48.19 ± 0.21%. The antinutrient parameters evaluated in the leaves were phytic acid (2.32±0.16) %, saponin content (1.36±0.25 %), alkaloidal contents (0.27±0.06) and oxalate content (0.23 ± 0.10) %. The predominant mineral elements in the leaf powder according to ICP-MS were Ca (45.26 mg/100g), Mg (15.80 mg/100g), and Na (13.31 mg/100g). Lead and arsenic contents were not detected in the leaves Rivea. Hence the outcome of this study revealed that R. hypocrateriformis leaves could be a valuable Neutraceuticals supplement and a cheapest source of essential nutrients to the human diet.

Macronutrientsproximate analysiselemental analysisoxalate content and ICP-MS
336,300 views
100,956 downloads

Contributors:

 Ruchika Garg
,
 Naresh Kalra
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