surfactants

The aimed to formulate and evaluate herbal shampoo because synthetic may causes the adverse effect on hair and scalp. The herbal shampoo was formulated by extracting murraya koenigi, sapindusmukorossias foaming agent, also addition of preservative agent. Citric acid used as viscosity modifier and pH adjusting agent and glycerin used as conditioning agent. HPMC(hydroxyl propyl methyl cellulose) used as thickening agent. The formulation at laboratory scale was done and evaluated for number of parameters such as pH, foam formation, viscosity, conditioning and wet ability were evaluated, and also to ensure its safety and efficacy

Oral route is the easiest and most convenient route for drug administration.  The major problem in oral drug formulations is low and erratic bioavailability, which mainly results from poor aqueous solubility. This may lead to high inter and intra subject variability, lack of dose proportionality. It is estimated that 40% of active substances are poorly water soluble. The solubility of such drugs is increased by formulating self emulsifying drug delivery system (SEDDS). Self emulsifying drug delivery systems have gained exposure for their ability to increase solubility and bioavailability of poorly water soluble drugs. SEDDS are isotropic mixtures of oil, surfactants, solvents and co-solvents/surfactants, which emulsify to produce fine oil-in-water emulsions upon gentle agitation. SEDDS typically produce emulsions with a droplet size between 100–300 nm. Solid SEDDSs are being developed from liquid/semisolid SEDDS mainly by adsorption on solid carriers, spray drying, lyophilization, melt extrusion, and nanoparticle technology. This review focuses on newer approaches for development of SEDDS and Solid SEDDS.

Self nanoemulsifying drug delivery (SNEDDS) is used for drugs which exhibit low water solubility. Dissolution is the rate limiting factor for these drugs. SNEDDS are capable of improving the bioavailability substantially of such drugs. They are formulated by utilizing an oil phase, surfactant and a co-surfactant. This formulation forms nano emulsion (O/W type) on contact with aqueous body fluids i.e. gastric juices when administered orally. Solid SNEDDS (s- SNEDDS) can also be formulated in the form of tablet which shows greater advantages. With recent and potential future developments, this technology will continue to enable novel applications in drug delivery and overcome limitations associated with the delivery of poorly water soluble drugs, mainly those belonging to BCS class-II and class-IV.

Self nanoemulsifying drug delivery (SNEDDS) is used for drugs which exhibit low water solubility. Dissolution is the rate limiting factor for these drugs. SNEDDS are capable of improving the bioavailability substantially of such drugs. They are formulated by utilizing an oil phase, surfactant and a co-surfactant. This formulation forms nano emulsion (O/W type) on contact with aqueous body fluids i.e gastric juices when administered orally. Solid SNEDDS (s-SNEDDS) can also be formulated in the form of tablet which shows greater advantages. With recent and potential future developments, this technology will continue to enable novel applications in drug delivery and overcome limitations associated with the delivery of poorly water soluble drugs, mainly those belonging to BCS class-II and class-IV.