solvent casting method.

The present investigation deals with the formulation of mouth dissolving oral films of Rizatriptan which is used for the treatment of migraine. Rapidly dissolving films have acquired great importance in present scenario because of exclusive properties. The films of Rizatriptan were carried out using different grades of HPMCE3, E6, and E15, maltodextrin DE6, xanthan gum and other polymers by solvent casting method.  The prepared films were evaluated for film thickness, folding Endurance, Surface pH, morphological properties, %drug content and content uniformity, tensile strength, percent elongation, in vitro disintegration time and in vitro dissolution studies. The optimized formulation F24 prepared using HPMC E15 showed minimum disintegration time (9 sec), highest dissolution rate i.e. 99.6% of drug within 8 min and satisfactory physicochemical properties. The optimized film was evaluated for its bioavailability compared with pure drug as reference standard. Statistical analysis declare that no significant difference between the bioavailability parameters Cmax, Tmax, AUC0–∞ and AUC0–t of the test film (F24) and the reference product (Pure drug) indicated that they exhibited comparable plasma level-time profiles. These results revealed that the mouth dissolving film containing Rizatriptan is considered to be effectively useful for the treatment of migraine where quick onset of action is expected.

The present work aimed at preparing fast dissolving buccal films of Isradipine solid dispersion, since Isradipine is a poorly soluble drug and the rate of absorption is often controlled by the rate of dissolution. The purpose of developing a dosage form for a very quick onset of action and for improved bioavailability along with the convenience of administration i.e. without the problem of swallowing and using water. The rate of dissolution can be increased by incorporating the drug in a fast dissolving buccal film as a solid dispersion that prepared using polyethylene glycol (PEG4000) or polyvinyl pyrrolidone (PVP k30). The fast dissolving films of Isradipine solid dispersion were prepared by solvent casting method using Lycoat RS720 polymer and glycerin as a plasticizer. The formulated films were evaluated for their physiochemical parameters like disintegration time, surface pH, thickness & weight of the films, percent moisture absorption, folding endurance, drug content and stability testing. Different factors affecting the dissolution rate of solid dispersion and fast dissolving film were studied. It was seen that as the ratio of drug to PEG4000 or PVP k30 in solid dispersion increased the release rate increased and the solvent evaporation method gave greater drug release than fusion method. In fast dissolving film it was seen that as the concentration of Lycoat RS720 increased the release rate decreased and as the concentration of glycerin increased the release rate increased. Formulation F6 showed 98.89% drug release from the film within 7 minutes which is an essential character for faster absorption.