solubility enhancement

Enhancement of the solubility, dissolution and bioavailability of the drugs is the challenging task for the research sector. As many of the solubility enhancement techniques are available to achieve the desired goal, but the older techniques don’t show the expected results for solubility enhancement and bioavailability as well, and they are unstable also some time.  But today the scenario is different because the novel techniques of solubility enhancement are available, such as hydrotropy, supercritical fluid process, sonocrystallisation, inclusion complex system, spray drying, microwave assisted techniques, etc. this novel techniques have the ability to give the reproducible results for solubility enhancement in pharmaceutical product development.  present review article deals with the different techniques for the solubility enhancement of the poorly soluble drug candidates.

  The objective of present study is to improve the dissolution rate of Acyclovir a poorly water soluble drug by solid dispersion technique using a water soluble carrier, PEG-6000, urea, mannitol. The solid dispersions are prepared by physical method, co-grinding method and solvent evaporation method. The prepared solid dispersions showed an enhancement in dissolution rate and solubility compared to plain drug. In vitro release profiles of all SDs were comparatively evaluated and also studied against pure acyclovir. Faster dissolution was exhibited by solid dispersion containing 1:4 ratio of drug: PEG-6000. The increase in dissolution rate of the drug may be due to increase in wettability, hydrophilic nature of the carrier and due to reduction in drug crystallinity. The prepared solid dispersion was subjected for % practical yield, drug content, infrared (IR) spectroscopic, differential scanning calorimetry (DSC). FT‐IR spectra revealed no chemical incompatibility between drug and PEG-6000.Drug– polymer interaction was investigated using differential scanning calorimetry (DSC) studies. Key words: Solid dispersions, carriers, solubility enhancement, poorly soluble drugs, bioavailability