mucoadhesive buccal tablet

The objective of this study was to develop effective buccoadhesive bilayered tablets of Eletriptan hydrobromide containing bioadhesive layer and drug free backing layer, expected to release the drug in unidirectional for extended period of time. Buccoadhesive tablets were prepared by using HPMC K4M, Carbopol 941NF and Carbopol 974p as mucoadhesive polymers with varying concentrations. The formulations were tested for in-vitro drug release, bioadhesive strength, moisture absorption, residence time and drug permeation through porcine buccal mucosa. Optimized formulation F3 of HPMC K4M showed maximum release of the drug (97.83±0.41), best fit in the peppas model and permeated 73.52% of the drug through porcine buccal membrane.