hypoglycemic activity

The present investigation was aimed to develop Glipizide loadedproliopsomal carrier system for Transdermal drug delivery which, deliver the drug effectively over an extended period of time to improve the anti diabetic effect of the loaded drug. Glipizide loaded proliposomal  gel was prepared by coacervation-phase separation method using different combinations of drug, sorbitol with cholesterol and lecithin (GF1 – GF6). Proliposome formulations were characterized for physical appearance, pH, vesicle size, entrapment efficiency, drug content uniformity, surface morphology, zeta potential analysis, in-vitro drug release, skin irritation test, and hypoglycemic activity. Among the different formulation, GF2 formulation showed more entrapment efficiency and drug content compared to all other formulations.  The optimized formulation GF4 showed maximum reduction in blood glucose level 101.83 ± 0.983at 24 hrs as compared to oral drug. Proliposomal gel (PLG1) showed no skin irritation and delivered the Glipizide in a controlled manner as compared to conventional dosage form, as evidenced by a significant decrease in blood glucose level in diabetes rats. Thus proliposomal gel will be suitable drug delivery system for Glipizide due to ease of preparation and incorporation of less number of excipients.