herbal formulation

The present study was designed to investigate the cardioprotective effects of herbal formulation in rats with isoproterenol-hydrochloride (ISPH) induced myocardial infraction. Adult male Wistar Albino rats were pre-treated with herbal formulation daily for a period of 4 weeks. After the treatment period, ISPH (85 mg/kg) was subcutaneously injected into the rats at 24 h intervals for 2 days. ISPH induced myocardial damage indicated by cardiac marker enzyme activities including creatine kinase-MB, lactate dehydrogenase, SGOT, angiotensin converting enzyme. The activities of antioxidant enzymes such as superoxide dismutase were significantly decreased in hearts after ISPH-induced myocardial infraction. However, pre-treatment of ischemic rats with herbal formulation brought the biochemical parameters to near normalcy, indicating the protective effect of herbal formulation against ISPH-induced ischemia in rats.

Species of the genus Cordial, Boraginaceous, are widely studied with regard to the formulation of herbal aqueous gel with using guava leaves extract. Herbal medicines is still the mainstay of about 75-80% of the world’s population, mainly in developing countries, for primary health care because of better compatibility with human body, cultural acceptability and lesser side effects. They are found principally in tropical and subtropical regions of the India, American and African continents, where they occur in various countries. The objectives of present investigation were to formulate and evaluate herbal gel for mouth ulcer treatment of dried powered of Cordial. All species of the genus Cordial, Boraginaceous, are widely studied with regard to the various Cordial dichotomy, guava leaves and Carbopol 934, Propylene glycol as a gel base. Formulations were evaluated for various parameters like physical appearance, pH, homogeneity, spreadability, viscosity, extrudability. The formulated gel was transparent, homogeneous and pH ranges from 7 to 7.5. Formulation showed acceptable rheological behavior with applicable spreadability and extrudability properties. Present herbal formulation was developing with very safe with good stability and effective over to synthetic formulations for the treatment of mouth ulcer. This research work give to information reported in this work contributes scientifically to recognizing the importance of the genus Cordial and guava as a target in the search for new biotechnological investments and herbal formulation.