gliclazide

Tablet is the most popular dosage form of all existing dosage forms , but in some cases due to the large size of dosage forms, in case of uncooperative, pediatric and dysphasia patients, it may create  problems, to overcome this , a new form of dosage form is developed, which is known as fast dissolving tablets or mouth dissolving tablets. These dosage forms are also used to attain instant higher concentration of drug in body for immediate actions. Gliclazide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). Fenugreek seed powder was added to this formuation because of  its various pharmacological benefits as well as its self disintegrating property. Mouth dissolving tablets were prepared using direct compression method .Formulations were optimized to develop tablets having minimum possible disintegration time. Tablets were evaluated for hardness, weight variation, friability, wetting time, disintegration time and stability. The main objective of the present research is formulation and evaluation  of mouth dissolving tablets of gliclazide which is an antidiabetic drug ,containing fenugreek seed powder as disintegrating agent.

  This present investigation deals with the design, development and evaluation of multiple unit beads containing gliclazide. The various gliclazide beads were prepared by ionotropic gelatin technique using sodium alginate, guargum and magnesium stearate in different ratios. These multiple unit beads were evaluated for size analysis, drug entrapment efficiency and in vitro drug release in simulated gastric fluids (pH 1.2) and phosphate buffer (pH 7.4). All these formulated showed sustained in vitro drug release in simulated gastric fluid over 6 hours. The gliclazide release was found to be more sustaining with the reduction of guargum content in the formulation .The drug release pattern of these multiple unit gliclazide beads (F-6 and F-7) were correlated well with first order model where F-1, F-4, F-5, F-8 and F-2 toF-3 was correlated well with Korsmeyer-Peppas model and Higuchi model with  non-Fickian diffusion mechanism. All the experimental results showed that the gliclazide loaded beads successfully sustain the drug release along with improve the oral bioavailability of candidate drug.