fast dissolving tablets.

The purpose of this research was to develop fast dissolving tablets of labetalol hydrochlorideis a phenyl ethanol amine derivative that is a competitive inhibitor at both β1 and β2 adrenergic receptors and at the α1-adrenergic receptor. Labetalol is an antihypertensive drug and the dose is 50-200mg twice/day with food. From the present study, the drug content was uniform in all the labetalol FDT formulations prepared. The drug and super disintegrating agent ratio was found to influence the release of drug from the formulations. As the level of super disintegrating agent and disintegrant changed, the drug release rates were found to be increased in all formulations. The prepared tablets disintegrate within few seconds without need of water; thereby enhance the absorption leading to its increased bioavailability. Key words:  Labetalol, antihypertensive, super disintegrating agent, fast dissolving tablets.