electrolytes

The impact of crude oil mixed meal on cellular status and oxidative stress markers in rat’s heart homogenates was studied. 35 Wistar rats of similar weight were randomly divided into 7 groups as follows; Group 1 control (normal chow), Group 2 (Treated with 3.88g/kg crude oil mixed meal), Group 3 (Treated with 7.75g/kg crude oil mixed meal), Group 4 (Treated with 15.51g/kg crude oil mixed meal), Group 5 (Treated with 32.01g/kg crude oil mixed meal), Group 6 (Treated with 62.02g/kg crude oil mixed meal), and Group 7 (myocardial infarct-induced group). Treatments in various groups were administered for 8 weeks (exposure period) and were later withdrawn for 2 weeks (withdrawal period). 5 ml of blood was taken from all groups via cardiac puncture in both phases for analysis for electrolytes estimations, haematological parameters, lipid profiles, and liver enzyme assay. Heart tissues were taken and homogenized and prepared for cardiac oxidative stress markers analysis, were extrapolated and calculated. Results from various laboratory analyses were statistically analysed using ANOVA (SPSS) and presented in tables and charts with level of significance at P ≤0.05. Haematological indices, electrolytes liver enzymes profile, lipid parameters and oxidative stress markers all presented marked increase during the exposure phase of six weeks. In the withdrawal phase, virtually all the above measured parameters were reversed and the corresponding biological effects ameliorated. The implications of the above extrapolates in both phases indicated that crude oil exposure could trigger, electrolyte imbalance, cellular disruptions, liver assault, and can be highly detrimental and delirious to cells while withdrawal from the contaminated meal was observed to reversed the entire scenarios. In conclusion, crude oil contaminated feed on cardiovascular integrity and risk factors could be a huge challenge and a potent pre-disposing scenario to various debilitating diseases of the heart on prolonged exposure.

AIM :Febrile  seizure  is  the  one  of  the  most  common  convulsive  disorders, mainly  occur  following  high  fever  without  any  evidence  of  underlying  health  issues, typically   in  the  children  of  age  of  upto  6  years. The  aim  of  this  study  was  to  assess the  relationship  between  variable  causative  factor  involved  in  the  incidence  of  febrile  convulsions between the  children  referred  to  Cosmopolitan Hospital, Thiruvananthapuram, Kerala (India). This  was  a hospital  based  prospective  observational  study. The  main  purpose  of  this  study  was  to identify  the  relationship  between  variable  risk  factors  associated with febrile  convulsion  in  children. The  children  of  age  upto  6 years  were  studied  to  assess  the  relationship  between  the  types of seizure ,gender ,electrolytes  and  variable  disease  conditions  which  leads  to  the  development  of  convulsive  event  in  children. The age and febrile seizure has a correlation that the children below 3 years is more hospitalized with febrile seizure. Viral fever associated febrile seizure shows more prevalence. Type of seizure and gender do not have any positive correlation in this study. Lab data provide significant positive correlation with the incidence febrile seizure. Pregnancy related complications and antenatal and natel complications also shows a significant relationship to the febrile seizure. Decreased breast feeding in the children also leads to the events of febrile seizure. family history of febrile seizure also provide a major relationship with febrile convu. Risk factor such as age, body temperature, family history, breastfeeding, low birth weight, cesarean, lab data’s that are involved in the development of febrile seizure were identified.