dispersion time

An immediate action of Metformin HCl is essential for emergency treatment of diabetes. With an objective of finding the best suitable disintegrant for immediate release tablet of Metformin HCl, different formulations were prepared by incorporating varying ratios of three widely used superdisintegrants both by intra and extra granularly. Wet granulation method was adopted to formulate the tablets by using Maize Starch as diluent; Povidone k-30 as binder; Sodium Starch Glycolate/Kollidon CL/Crosscarmellose Sodium as superdisintegrants in different concentration (2-3.5%), Aerosil-200 as flow promoter and Magnesium Stearate as lubricant. To evaluate the rheological properties of powdered blend, some pre-compression characteristics including bulk and tapped densities, compressibility index, Hausner’s ratio, angle of repose were studied. The compressed tablets were evaluated for hardness, thickness, diameter, friability, drug content, weight variation, in vitro dispersion time, in vitro disintegration time, in vitro wetting time and finally for in vitro dissolution studies. It was found that wetting time, dispersion time and the disintegration time of the tablets were governed by the type and quantity of the superdisintegrants. In vitro drug release data obtained at phosphate buffer at pH 6.8 also found reliant on successful incorporation of right disintegrating agent. Higher the disintegrant ratio in the formulation, lower the disintegration time and hence, higher percentage of drug release was obtained. Based upon results of different studies, Sodium Starch Glycolate has been proven successful in rapid disintegration of tablets and enhancing dissolution behavior.

  The purpose of this research was to introduce and evaluate natural excipients (soy polysaccharides, CP) that have versatile property in the orally disintegrating tablets. The main objective of this work was to assess the excipient for its activity as a disintegrant and compare its properties with other synthetic superdisintegrants. Orodispersible tablets containing a model drug, Lornoxicam was prepared using different ratios of banana powder, soy polysaccharides, crosspovidone, croscarmellose sodium (CCS) and sodium starch glycollate (SSG) as disintegrants. The prepared tablets were evaluated for their physiochemical properties like wetting time, water absorption ratio, dispersion time, disintegration time and drug release studies. It was observed that the results obtained from formulations containing the soy polysaccharides and CP as superdisintegrant showed a better profile in comparison to banana powder, CCS and SSG. Disintegration time of the formulations varied from 15 to 36s for all the formulations. Dissolution studies suggested that the drug dissolution from formulations containing soy polysaccharides was more than 90% within 15min in comparison to 82% and 85% for CCS and SSG respectively. Stability studies of the prepared tablets showed non-significant drug loss and drug release. Hence, it was concluded that banana powder can be used as a natural disintegrant in orodispersible tablets. The excipient being available naturally and having nutritional benefits adds value to the formulation and can be utilized as an effective excipient in preparing tablets with less cost.