disintegrant

The aim of the current study was to isolate mucilage from five different plants, which was done by maceration, followed by incorporating the extracted mucilage into a tablet formulation and to study its disintegrant property. Comparative results were obtained and varying degree of disintegrant action was observed among the five subject plant sources. It was found that Lepidum sativum seeds showed the highest yield of 12.5%w/w as compared to the remaining four plant products. Additionally, the disintegration time of tablets formulated from mucilage obtained from Lepidum sativum was found to be the least and the tablets disintegrated in 25 seconds. Mucilages are very hydrophilic and are capable of trapping water in their cage-like structures to form a gel. Consequently, when mucilage is mixed with water it swells to many times its original volume as it absorbs water1. Mucilages find applications in numerous pharmaceutical preparations and perform their role as disintegrants, sustained-release agents, binders, mucoadhesives, to name a few2.

The objective of this study was to develop and evaluate a pulsatile drug delivery system based on drug-containing core tablet, which were coated with a swelling layer. Core tablets of Salbutamol Sulphate were prepared by direct compression using a croscarmellose sodium as disintegrant, micro crystalline cellulose as diluent and other. Core tablets were evaluated for uniformity of weight and thickness, hardness, friability, disintegration and dissolution. Compression coating over the prepared core tablets were done using various grade of HPC. Different formulae S1 to S9 were prepared using different coat % weights gain and polymer ratio. The compression forces were kept constant by adjusting constant distance between the upper and lower punches. The prepared Salbutamol Sulphate tablets were evaluated for the Lag time and in vitro release characteristics at variant pH media mimicking the gastrointestinal media. The results showed that the developed core tablets of Salbutamol Sulphate comprised excellent physical characteristics and complied with the USP criteria. For the pulsatile system, a quick releasing core was formulated in order to obtain a rapid drug release after the rupture of the polymer coating. The lag time prior to the rapid drug release phase increased with increasing % coating level. Key word: disintegrant, swelling layer, pulsatile release tablets, compression coating, lag time.