diketones

A simple and efficient protocol for the synthesis of 1,4-dihydropyridines has been developed. In this one-pot multicomponent condensation methodology, all the reactants aldehydes, β-ketoester, ammonium acetate and catalyst were subjected to react at acetonitrile reflux to afford the corresponding products in very good yields. In all reactions, the catalyst Zn(OTf)2 was used in catalytic amount only and all the products were characterized by their spectroscopy analysis.  

A simple and efficient methodology for the synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives has been developed by the condensation of aldehydes, ethyl acetoacetate  and urea using Germanium (IV) iodide as catalyst. All the reactions were carried out at acetonitrile reflux and completed within 2 to 5 hours of reaction with good yields. All the products were very clear and confirmed by spectroscopy analysis.