diazepam

The present study was undertaken to evaluate Anxiolytic activity of methanolic extract of caltropis gigantea flowers. Of caltropis gigantea (200,400 mg/kg) was studied. Diazepam used as a standard drug (2mg/kg), by using EPM Model. The diazepam and all the doses of extract had showed significant Anxiolytic activity the finding this experimental animal study indicates that caltropis gigantea posses Anxiolytic activity

Mucuna pruriens commonly known as cowhage plant has been claimed to possess various beneficial effects like anti-parkinsonian, anti-tumor, neuroprotective, antioxidant, anti-diabetic and antidepressant activities. Previous studies have reported that Mucuna pruriens contains L-DOPA and 5-hydroxy tryptophan (5-HT) as a major constituent with higher concentration in seeds. However, literature search revealed no scientific data on its anxiolytic activity. So the present study was designed to evaluate the anxiolytic activity of Mucuna pruriens in a murine model. Wistar albino rats were divided into five groups (n=6). Mucuna pruriens administered at doses of 250,500,750mg/kg/day orally, was compared with the standard drug Diazepam (1.0mg/kg/day, oral) fed for 14 days. Three pharmacologically validated models elevated plus maze, bright and dark arena and open field test were used. The data presented was analyzed using one way ANOVA followed by Dunnett’s post hoc test. A value of p