chalcones

The substituted chalcones (C1-5) was prepared by reaction of acetophenone (a) and aromatic aldehydes (b1-5). One series of N-phenyl pyrazoline analogues (K1-K5) were synthesized by reaction of the substituted chalcones (C1-5) with phenyl hydrazine in acidic medium. Another series of 3, 4-dihydropyrimidine-2-one analogues (K6-K10) were synthesized by reaction of substituted chalcones (C1-5) with ethanolic urea in alkali medium. The yield of the synthesized analogues ranged from 62-76%. The structures of the synthesized analogues were verified by FTIR,1H-NMR, mass spectral data and physical analysis. The structures of the synthesized heterocyclics are correlated with the spectral analysis and the synthesized heterocyclics structures are well agreed with the proposed structure.

Microwave assisted solvent free synthesis of cyclohexenone and indazole derivatives were carried out by chalcones derived from different acetophenones and 1-naphthaldehyde. Structures of the compounds have been characterized by IR, 1H NMR, Mass spectrometry and elemental analysis. All the synthesized indazole derivatives were screened for antibacterial activity and are found to posses moderate to good activity against some species of bacteria.

In present study, a novel series of 6-bromo-2,7,8-trichloro-3-(3’-phenyl-4’,5’-dihydro-1H-pyrazol-5’-yl)quinoline(a-i). These novel synthesized entities were elicited by IR, 1H NMR, 13C NMR, C,H,N Analyzer and mass spectra. The entities produced in laboratory were screened with strains of bacteria and fungi like Staphylococcus aureus, Bacillus Megaterium, Proteus vulgaris, Escherichia coli, and Aspergillus niger respectively. Out of nine different entities synthesized five derivatives showed excellent antibacterial activity and rest of them showed moderate antimicrobial activity.