antifungal.

The objective of the present research work is to formulate and evaluate Itraconazole antifungal gel. Itraconazole is an imidazole derivative and used for the treatment of local and systemic fungal infection. The oral activity of Itraconazole is not much proven to be efficient as it has many side effects. This formulation is made for better patient compliance and to reduce the dose of the drug. The gel was formulated by changing the polymer ratio. Various formulation (F1, F2, F3, F4) were developed by using a suitable polymer (carbopol 971p and noveonAA1). The formulation was evaluated for, spreadability, extrudability and viscosity in vitro drug release study. Viscosity studies of various formulations revealed that formulation F4 was better to compare to others. From among all the developed formulation, F4 shows better drug diffusion, did good Rheological properties. pH of the F4 formulation is sufficient enough to treat the skin infections. Results indicated that the concentration of carbopol 971p and noveon AA1 significantly affects drug release and rheological properties of the gel. It was concluded that formulation F4 was the best formulation among this formulation. Hence formulation F4 has shown the better results compared to other batches.

In the present study, a series of N-[5-(phenyl)-1,3,4-thiadiazole-2-yl] benzamide and N-[5-(phenyl)-1,3,4-thiadiazole-2-yl] acetamide were prepared by refluxing with benzoyl chloride and acetyl chloride with 5-phenyl-1,3,4-thiadiazole-2-amine. 5-phenyl-1,3,4-thiadiazole-2-amine were prepared by oxidative cyclization of thiosemicarbazone (through condensation of aromatic aldehyde and thiosemicarbazide). The structure of new compounds prepared during present investigation have been authentically established by their IR,1H-NMR and Mass spectral studies. The antibacterial and antifungal activities of thiadiazole derivatives also reported. Some of these derivatives exhibit significant antimicrobial activity. Key words:  Thiosemicarbazone, Thiadiazole, antibacterial, antifungal.

In the present study, a series of S-[5-(phenylamino)-1,3,4-thiadiazole-2-yl] benzenecarbothioate and S-[5-(phenyl amino)- 1,3,4-thiadiazole-2-yl] ethanethioate were prepared by refluxing benzoyl chloride and acetyl chloride in presence of potassium carbonate with 5-(phenyl amino)-1,3,4-thiadiazole-2-thiol. 5-(Phenyl amino)-1, 3, 4-thiadiazole-2-thiol were prepared by cyclization of arylthiosemicarbazide with carbondisulphide. The structure of new compounds prepared during present investigation have been authentically established by their IR, 1H NMR and Mass spectral studies. The antibacterial and antifungal activities of thiadiazole derivatives also reported. Some of these derivatives exhibit significant antimicrobial activity. Key words: thiadiazole, thiosemicarbazide, antibacterial, antifungal.  

  In the present study, a series of substituted 2-(1H-benzimidazol-2-ylsulfanyl)-N-phenylacetamide was prepared. The synthesis of titled compounds from starting material unsubstituted 2-mercapto benzimidazoles was prepared from o-phenylenediamine and carbon disulfide in presence of KOH in single step. 2-mercapto Benzimidazole on reacting with N-substituted-α-chloroacetanilides yield different derivatives of Benzimidazole. The structure of new compounds  prepared  during  present  investigation  have  been authentically established by their IR,1H NMR and Mass spectral studies. The antibacterial and antifungal activities of thiadiazole derivatives also reported. Some of these derivatives exhibit significant antimicrobial activity. Key words: 2-mercapto benzimidazoles, phenylacetamide, antibacterial, antifungal.

  A series of thiophene and aryl substituted compounds 1a-f; 2a-b and 3a-c were synthesized by Erlenmeyer azolactone synthesis. These compounds were screened for antimicrobial activity method in vitro. Among the tested compounds 3c showed significant activity and some of the other compounds showed promising activity. The structure of new compounds synthesized during present investigation have been authentically established by their IR,1H NMR and Mass spectra and some QSAR studies. Key words: Thiophene; antimicrobial; antibacterial; antifungal.