Venlafaxine hydrochloride

This study examines the sustained release behaviour of venlafaxine hydrochloride from Hydroxyl propyl methyl cellulose & sodium carboxy methyl cellulose. Venlafaxine hydrochloride is an antidepressant agent. The present research endeavor was directed towards the development of a sustained release dosage form of venlafaxine in the form of tablets to be taken once daily. All lubricated formulations were compressed by direct compression. The compressed tablets were evaluated for uniformity of weight, content of active ingredient, friability, hardness, thickness and In-vitro dissolution study. Release studies were carried out using USP type 2 apparatus in 900 ml of Distilled Water as dissolution media. Release kinetics were analyzed using zero-order, Higuchi’s square root and Peppa’s exponential equations. All formulations showed compliance with pharmacopoeial standards. Among different formulations F7 showed sustained release of drug for 12 hours with 99.73% of drug release respectively. The regression coefficient value of zero order plots was found to be 0.993. The slope of peppas model was found to be 0.981 for F7.Thus the matrix system of HPMC & SCMC was found to be effective in retarding release of venlafaxine hydrochloride.

The present study involves the formulation and evaluation of buccal tablets of venlafaxine hydrochloride, an antidepressant drug belongs to class SNRI(serotonin-nonepinephrine reuptake inhibitor)has high first pass metabolism, So buccal drug delivery has been considered an alternative to the oral dosing for compound subjected to degradation in the gastrointestinal tract or to first pass metabolism. An attempt has been made to developed muccoadhesive buccal tablets comprising of drug containing mucoadhesive layers and drug free backing layer ethyl cellulose of to release the drug for extended period of time with reduction in dosing frequency, dose related side effects and improve bioavaibility of drug. Tablets of Venlafaxine Hydrochloride were prepared by direct compression using muccoadhesive polymers Carbopol 934-P and HPMC K4M.Buccal tablets were evaluated by different parameters such as thickness, hardness, weight uniformity, content uniformity, swelling index, surface pH, ex vivo bioadhesive strength, in vitro drug release, ex vivo drug permeation and FTIR studies. The modified in vitro assembly was used to measure the bioadhesive strength of tablets with fresh goat buccal mucosa as model tissue. In order to determine the mode of release, the data was subjected to Krosmeyer and Peppas diffusion model. All the formulations followed Fickian release mechanism. Tablet containing Carbopol 934P and HPMC K4M in the ratio of 1:1(25%) had maximum in vitro drug release for 8 hrs.