Sucralfate

The preparation was to be started with the preparation of successive extract of plant leaves of Ficus Carica Linn. (Moraceae) in petroleum ether and ethanol respectively followed by pharmacological investigations including Organoleptic property and photochemical investigation i.e. test for triterpenoids, Glycosides, Alkaloids, Flavonoids, and Tannins. The % yield values for ethanolic leaves extract and petroleum ether leaves extract were found to be 3.6 & 5.4%. The anti-ulcer effect of ethanolic leaves extract of Ficus Carica Linn. Studied in Pylorus ligation and chemical (HCl-Alcohol) induced ulcer in albino rats. The extract at dose of 250, 500 mg/kg produced significant inhibition of gastric lesion by chemical and Pylorus ligation induced ulcer in rats and omeprazole and Sucralfate used as a standard drug. The extract reduced ulcerative lesion, gastric volume, free and total acidity but raised the PH of gastric juice in Pylorus ligation& chemical induced model. The obtained result for the  anti-ulcer activity of ethanolic leaves  extract were confirmed, and reduced ulcerative lesion, gastric volume, free acidity and total acidity  with the comparison of standard drug. The all significant were shows the ulcerative index, free & total acidity, percentage of protection, hemorrhage, streaks, as compared to control and also pH raised up to 3.5 respectively.