Solution of carrageenan

Three groups of rats each consists of five rats were used for this study. Edema was induced by injecting a solution of carrageenan in saline intradermally. Transdermal cellulose acetate phthalate film (with IPM as penetration enhancer) with highest drug release and organogels formulation (Fl: Span 60: 17; Tween 20: 3; Soya bean oil: 40; Drug: 2 and Water: 40) with the highest spreadability, the lowest viscosity and the optimized drug release over 8 h was applied. Results from the in vivo pharmacological study revealed that gel preparation was superior to the patch in reducing the edematous swelling in the rats feet pad over the 1 day of application.