Solid self-microemulsifying drug delivery system

The objective of the present study was to formulate a solid self micro emulsifying drug delivery system (SMEDDS) for oral administration to improve the solubility and bioavailability of Nimorazole. Solubility was determined in various oils, surfactants and cosurfactants. Of  all the oils accessed for drug solubility, Capmul PG 8 NF showed higher solubility for drug and was better microemulsified using combination of Labrasol and Labrafac CC surfactant. The optimal formulation consists of 30% Capmul PG 8 NF, 50% Labrafac CC,20% Labrasol , was adsorbed on carriers Aerosil200, Microcrystalline cellulose (MCC) and Kaolin .The SMEDDS and solid SMEDDS were characterized for Percent transmittance (%T). Those formulations which showed higher value for %T were evaluated for droplet size, polydispersity index, ζ potential, refractive index and cloud point measurement. Effect of drug loading on droplet size, increasing dilution in different media, thermodynamic stability and in vitro dissolution was performed to observe the performance of the selected formulation. The solid SMEDDS are characterized by globule size analysis, and drug release studies of formulations are compared with plain drug. Adsorption on kaolin produced SMEDDS with the desired globule size and drug release. There was an increase in both the solubility and dissolution rate of drug in S-SMEDDS-K3 as compared to dissolution rate of pure Nimorazole.

The objective of the present study was to formulate a solid self micro emulsifying of drug delivery system (SMEDDS) for oral administration to improve the solubility and bioavailability of Lamotrigine. Solubility was determined in various oils, surfactants and cosurfactants. Ternary phase diagrams were constructed to evaluate the micro emulsification existence area. The optimized formula is obtained by factorial design employed as statistical tool.  The optimal formulation consists of 20% Capmul MCM C8, 55% Labrasol , 25% Tween 80 was adsorbed on carriers Aerosil200, Microcrystalline cellulose (MCC) .The solid SMEDDS are characterized by globule size analysis, and drug release studies of formulations are compared with plain drug. The pharmacokinetic study in rats for the optimized formulation was performed and compared to plain drug powder. SMEDDS have significantly increased the Cmax and area under the curve (AUC) of Lamotrigine compared to powder (P < 0.001). Thus, this self-micro emulsifying drug delivery system should been effective oral dosage form for improving oral bioavailability of Lamotrigine. Key Words: Solid self-microemulsifying drug delivery system, Globule size, Dissolution, Oral bioavailability