Single step synthesis

A simple and efficient approach towards single step synthesis of pyrazolo[3,4-d]pyrimidin-4(5H)-one derivatives has been developed by condensation reaction of ethyl ester of 5-amino-1-substituted-1H-pyrazole-4-carboxylate with different aromatic nitriles under acidic conditions. All the newly synthesized compounds were characterized by spectroscopic techniques (IR, NMR and Mass spectra) and elemental analysis.