Propranolol Hydrochloride

Drug release retarding polymers are the key performers in sustained release drug delivery system for which various natural, semi-synthetic and synthetic polymers have been investigated. The use of natural polymers over synthetic has gained importance due to their biodegradable, biocompatible, cost effectiveness and safety considerations. The present study deals with isolation of mucuna gum from the species of Mucuna flagillepes (Papillionaceae) and evaluating its suitability as a microencapsulating agent for delivery of propranolol hydrochloride. The gum was extracted from mucuna seeds by using 1% sodium-meta bisulphite as solvent followed by precipitation with acetone. The extracted gum was evaluated for physical characteristics like melting point, solubility, pH, total ash and micromeritic properties. Propranolol hydrochloride, a non selective beta-adrenergic receptor blocking agent was chosen as a model drug for formulation of microspheres with different drug: polymer [1:1-2.5] ratios by emulsification solvent evaporation method. The microspheres were evaluated for yield, particle size, drug loading efficiency and in-vitro drug release studies. The drug-polymer compatibility was confirmed by IR spectroscopy. The yield of formulations was found to be between 79 to 90.3% with the average particle size between 55.8 to 74.5µm.The drug encapsulation efficiency of microspheres was found to be in the range of 67.7 to 89.9%. The in-vitro drug release studies revealed that the polymer had positive effect on the drug retarding efficiency. The selected microspheres showed sustained and complete drug release up to 12 hours. Thus mucuna gum as a natural biodegradable polymer proved to be a suitable drug release encapsulate.

In the present study, Solid Dispersion of Propranolol Hydrochloride were prepared using solvent evaporation technique using PEG 4000, PVP K-30 and PVA. However absolute bioavailability of Propranololo Hydrochloride is about 30% . To increase the solubility, solid dispersion was prepared. Preliminary solubility analysis was carried out for the selection of carriers and solid dispersion was prepared with PVA, PEG 4000, PVP-K30. These solid dispersions were analyzed for the solubility and In-vitro dissolution profile, solid dispersion of drug with PEG 4000 had shown enhanced solubility with improved dissolution rate. Further FTIR, DSC, SEM studies were carried out. Solid dispersion prepared with PEG 4000 shows the presence of amorphous form confirmed by the characterization study .The study also shows that dissolution rate of Propranolol Hydrochloride can be enhanced to considerable extent by solid dispersion technique with PEG 4000.