Physicochemical

Clopidogrel is an orally administered medicine that lowers the risk of heart disease. The production process is defined by drug quality, and every pharmaceutical business aims for it, although it is often difficult to attain. The purpose of this study was to look at the quality control parameters of several commercially available Clopidogrel tablets. Four distinct marketed brands of Clopidogrel 75 mg tablets available in the Mangalore market were collected from different pharmacies in Mangalore city to examine the quality. Weight variation, hardness, thickness, and friability, among other quality indicators, were determined according to established protocols. Then there was the in-vitro dissolution test, potency, and disintegration time. All of the brands met the requirements of the Pharmacopoeia since they had a weight fluctuation range that was acceptable. All brands were less than 1% friable, and there were no significant differences in disintegration times, since they all dissolved within 15 minutes. In terms of dissolution profile, all brands had an acceptable dissolving time, releasing more than 60% of the drug in less than 45 minutes. All brands’ hardness fell inside the range. All of the brands also meet the potency requirements. This investigation found that the majority of commercially available Clopidogrel pills in Mangalore are of good quality and meet pharmacopoeia requirements.

The present study was undertaken for the development of physicochemical and phytochemical parameters of the roots of Paederiafoetida [Linn] Belonging to the family, Rubiaceae. The plant commonly known as skunk vine is a perennial climber, in Sanskrit as Prasarni, in Marathi  as Hiranvel, in Hindi as Gandha Prasarini, in English as Chinese flower plant. The physicochemical and phytochemical investigation confirms the purity and authenticity of Paederiafoetidaroots by using standard methods. The physicochemical studies revealed the presence of moisture content as 6% w/w, total ash as 8.75 %w/w, acid insoluble ash as 1.1%w/w, water soluble ash as 1.8%w/w, alcohol soluble extractive as 9.8%w/w, water soluble extractive as 9.2%w/w, ether soluble extractive as 2.4% w/w, foaming index as less than 100 and swelling index as 1.7cm. The fluorescence analysis in short wavelength, long wavelength and day light is also reported, which is a tool to determine the chemical nature of crude drug. Preliminary phytochemical screening of the ethanolic extract of the roots revealed the presence of alkaloids, glycosides, carbohydrates, triterpinoids, steroids, tannins and resins. All these methods will help in setting down pharmacopoeial standards in determining the quality and purity of the Paederiafoetida roots.