Phyllanthus emblica

To evaluate Nephrpotective potential of Polyherbal methanolic extraction (Terminalia chebula, tinospora cordifolia, Phyllanthus emblica, Portulaca oleracea) against gentamicin (GM) induced Nephrotoxicity and renal dysfunction. It was observed that the GM treatment induced significant elevation (P

The present study aims to investigate the phytochemical screening, antioxidant and anti-diabetic activity of commonly used fruits, Musa acuminata Red Dacca (Red Banana), Citrus sinensis (Orange) and Phyllathus emblica (Amla). Edible part of Phyllanthus emblica, Musa acuminata Red Dacca and peel of Citrus sinensis are taken for the study. The phytochemical screening of ethanolic extract of Musa acuminata revealed strong presence of carbohydrates and glycosides and moderate presence of tannins, proteins, flavonoids, steroids and phenols. The ethanolic extract of Citrus sinensis showed abundance of flavonoids and least presence of carbohydrates, proteins and steroids. Strong presence of phenol was shown in Phyllanthus emblica and all the others were present in least amount. The antioxidant activity was determined by ferric reducing power assay (FRP) where Phyllanthus emblica showed maximum activity that was followed by Citrus sinensis peel and then Musa acuminata. α-Amylase inhibitory assay was performed to detect the antidiabetic activity of these fruits by comparing with  commercially available drug Okamet. It was Phyllanthus emblica that used lowest concentration to inhibit the enzyme which was found similar to positive commercial standard Okamet that is used for reducing blood sugar level. Hence it can be concluded that Phyllanthus emblica has good antioxidant and antidiabetic property than Musa acuminata and Citrus sinensis.

Kidneys are complex organs, which perform several important functions. Though the formation of urine is their most obvious role, but they also perform the vital co-ordination of water and salt metabolism, acid-base balance and secretion of hormones. The effects of occupational or therapeutically exposure to toxic metals on kidney have been known for many years. A large number of chemicals in common usage are potential nephrotoxic viz. Glycols (plastics solvents), paints, lacquers, cosmetics and flavouring extracts. The nephropreotective activity of the poly herbal formulation (composed of the extracts from Terminalia chebula, tinospora cordifolia, Phyllanthus emblica, Portulaca oleracea) was evaluated in Gentamicin induced nephrotoxicity in rats, Gentamicin like other aminoglycoside antibiotics causes nephrotoxicity by inhibiting protein synthesis in renal cells. The serum creatinine and blood urea nitrogen (BUN) were found to be significantly increased in rats treated with only gentamicin, whereas treatment with PHME the effect of gentamicin indicating nephroprotective activity. Among various doses, 200mg/kg, 400mg/kg has shown good nephroprotective activity.