Novel drug delivery

The major objective of any dosage form development is to ensure the delivery of specific and reproducible amounts of pharmacologically active compounds to the body in the maximum amount possible. Today's most frequently used dosage forms are orally administered solids formulated such as tablets, capsules or powders. Timed-release products intend to improve delivery efficacy and/or effectiveness; for instance, the frequency of dosing can be reduced and, in certain cases, the actual daily dose can be reduced, offering the manufacturer a financial benefit. There have been many techniques developed for producing the variety of timed-release products. Ginger is a natural drug, which is used for nausea and vomiting, to treat bleeding disorders and rheumatism. In conventional dose is thrice a day, 8-10 gm which is not at all convenient for the patient. Increase the patient compliance is also a great challenge which is continuously improving by the novel drug delivery system. The main objective of the present work is to design Ginger root extract powder (5%w/w of 6-gingerol) timed release dosage form of the drug with the help of a novel clear transparent veggie capsule shell of ‘0’ size made up of cellulose and natural substance. The objective in formulating a sustained release dosage form is to be able to provide a similar blood plasma level pattern for up to desired hrs (12hrs) after oral administration of the drug. The formulation, optimization, destructive quantification parameters and in-vitro studies of the drug have focused in this research article. The presented work sought a futuristic research for the benefit of the patients.

Polymers have been used as a main tool to control the drug release rate from the formulations. Extensive applications of polymers in drug delivery have been realized because polymers offer unique properties which so far have not been attained by any other materials. Advances in polymer science have led to the development of several novel drug-delivery systems. A proper consideration of surface and bulk properties can aid in the designing of polymers for various drug-delivery applications. These newer technological developments include drug modification by chemical means, carrier based drug delivery and drug entrapment in polymeric matrices or within pumps that are placed in desired bodily compartments. These technical development in drug delivery/targeting approaches improve the efficacy of drug therapy thereby improve human health. Polymer chemists and chemical engineers, pharmaceutical scientists are engaged in bringing out design predictable, controlled delivery of bio active agents. Biodegradable polymers have been widely used in biomedical applications because of their known biocompatibility and biodegradability. In general natural polymers offer fewer advantages than synthetic polymers. The following review presents an overview of the different biodegradable polymers that are currently being used, their properties, as well as new developments in their applications.