Mamira

Present study was design to investigated In vitro antioxidant activity of hydroethanolic (HEETF), methanolic (METF) and aqueous extracts (AQETF) of Thalictrum foliolosum family-Ranuculacaece. Traditionally used for jaundice, antimalarial, antipyretic, Diuretics, dyspepsia and febrifuge was found in scientific literature. The antioxidant activity (AA) was determined by the possible four complementary test assay methods namely total phenolic content, total flavonoid content, Inhibition of  2,2 diphenyl -1 picrylhydrazyl (DPPH) radicals and ABTS (2-2’- azinobis) radical scavenging activity or quenching activity .Total phenolic content were found in HEETF, METF and AQETF 43.64±24.2, 53.64± 32.8 and 55.82±30.6 respectively, result shows as mg/GAE/ g of extract. Total flavonoid content  were found in HEETF, METF and AQETF 25.43±31.3, 33.42± 29.3 and 42.67±31.8 respectively, result shows as mg/Rutin /g of extract.  In DPPH radical scavenging activity, IC50 value were found in HEETF, METF and AQETF 4.270µg/ml, 4.90 µg/ml and 5.170 µg/ml respectively, in ABTS 2-2’- azinobis radical scavenging activity value were found in HEETF, METF and AQETF  3.35µg/ml, 3.58µg/ml and  4.86 µg/m respectively. The present study revealed that hydroethanolic extract shows significant Antioxidant, Thus it provides a platform for further research, it could be a potential candidate for further drug development