Incidence

Epilepsy is a disorder that is best viewed as symptoms of disturbed electrical activity in the brain, which may be caused by a wide variety of etiologies. It is a collection of many different types of seizures that vary widely in severity appearance, cause, consequence an management. The present study was done to evaluate, which drug is more effective than the other AED, used in tertiary care hospital. We studied and analyzed the pattern usage of AED in tertiary care hospital.  And evaluated the incidence of side effects of these drugs on the subjects in the study, studied the compliance to various recommendations/protocols for usage of AED in neurology intensive care unit, and also compared the commonest and least common anti epilepsy drugs in neurology care unit. Commonest drugs use in TBI, CVA, SAH, average age of patients having seizures. The required information was collected from the case sheets of individual patients in the designed data collection form. Patient details were collected through self designed, by patient interview, by prescriptions or by medication charts. The efficacy study conducted and was evaluated according to the declaration of ”HELNSIKI” (as embedded 1996) an by the incidence of adverse event reported by the patients.

To study the effect of co morbidities, quality of life, motor and cognitive dysfunction and assess the influence of age, gender in stroke patients. Observe prescribing pattern of drugs. Patients were evaluated for following parameters Age, Gender, Motor FIM, Cognitive FIM, QOL, Comorbidities. Comorbid conditions were assessed using CCI. Patient’s disability was assessed using FIM. The ADL was recorded according to Katz Index. Different Prescription patterns were identified. The incidence of stroke is maximum in the age group of 51-60 years which comprises 30% patients. Stroke is more common in males than females. Smoking and Alcoholism were detected as most common risk factors. FIM Scores of physical and cognitive disability are useful to measure patient’s progress and showed improvement or functional gain in the patients. Hypertension and Diabetes Mellitus were most frequent comorbidities in Stroke. Various classes of drugs were administered to patients. Calcium channel blockers, Beta Blockers, Diuretics, ACE Inhibitors, ARB’s and combinations. Phenytoin, Piracetam, Mannitol, Atorvastatin, Aspirin, Enoxaparin were prescribed. There should be a standard stroke pharmacotherapy for better usage and patient compliance. The incidence of Stroke has significant impact in the quality of Life of the patients. Various risk factors associated with Stroke and presence of comorbidities deteriorate the patient’s progress. FIM scores clinically assess physical and cognitive disability. The standard prescribing patterns should be followed for pharmacotherapy to improve patient care.