In vitro drug release.

  Transdermal films of Diclofenac Sodium were formulated by using Hyptis suaveolens seeds mucilage as film forming agent in various concentration. According to the research articles and mucilage can be used as film forming agent. Hyptis suaveolens seeds mucilage is naturally occurring polymer containing polysaccharide which cannot be used as film forming agent before. There are tremendous researches on natural polymers in today’s world because of various advantages of natural polymer over synthetic. Therefore we can take it for further examination as film forming agent and its evaluation. Drug polymer interactions determine by using FTIR and DSC. The medicated films were evaluated for physicochemical properties and also medicated films were evaluated for area variation, drug content and percent cumulative drug release. In vitro drug release study through cellophane membrane indicates that hydrophilic polymer showed higher release. The release rate found to follow first order rate kinetic. The prepared patches will evaluated for thickness, folding endurance, tensile strength, drug contain uniformity, in-vitro permeation study. In vitro drug release study was performed by using artificial membrane.

Conventional drug therapy requires periodic doses of therapeutic agents. These agents are formulated to produce maximum stability, activity and bioavailability.  Floating drug delivery systems (FDDS) have a bulk density less than gastric fluids and so remain buoyant in the stomach without affecting gastric emptying rate for a prolonged period of time. While the system is floating on the gastric contents drug is released slowly at the desired rate from the system. The present study mainly focuses on the development and evaluation effervescent based floating matrix tablet of famotidine. This oral drug delivery offers several advantages over the standard conventional oral dosage forms. Effervescent based floating matrix tablet of famotidine was prepared using sodium bicarbonate as effervescent agent and by incorporating hydrophobic agent stearic acid which retards the drug release and allow the dosage form to float on gastric fluid for several hrs. Then the tablet was evaluated for hardness, friability, drug content and in vitro drug release. On the basis of the preliminary trials, a 32 full factorial design was employed to study the effect of independent variables, HPMC K4M: Carbopol 934P ratio (X1) and concentration of effervescent agent (X2) on dependent variables like floating lag time, Q4 and Q8. The best batch (F3) exhibited optimum floating lag time (16 sec), drug content (98.94%), Q4 (54.36 %), Q8 (93.98%) and similarity factor (83.92). The controlled release of famotidine was observed and good fit to the zero order was demonstrated.