Higuchi.

Present study aims to prepare and evaluate Metoprolol succinate microspheres by ionotropic gelation method. Among all the formulations S7 was selected as optimized formulations for based on the physico chemical parameters and drug release studies. In the in vitro release study of formulation S7 showed 96.29% after 12 h in a controlled manner, which is essential for disease like peptic ulcer. The in vitro release profiles from optimized formulations were applied on various kinetic models. The best fit with the highest correlation coefficient was observed in Higuchi model, indicating diffusion controlled principle. FT-IR and DSC analyses confirmed the absence of drug-polymer interaction. The results obtained from evaluation and performance study of different types of Metoprolol succinate microspheres that system may be useful to achieve a controlled drug release profile suitable for peroral administration and may help to reduce the dose of drug, dosing frequency and improve patient compliance when compared with marketed product.