Heavy metal

Cassia angustifolia is popularly known as senna, since its leaves and pods are common laxatives, they are widely used in medicine and as a household remedy for constipation all over the world popularly in Europe and US. It is available in various dosage forms such as tablets, capsules, granules, liquids and in combination with other laxatives. The objective of the present research work is to develop a preservative free formulation with direct compression approach, complying to USP dissolution test, microbiological purity and standards of heavy metals laid down by WHO. The tablets prepared by direct compression approach are economical, have minimum processing steps, faster disintegration, rapid onset of action and complying to all other tablets parameters.

Traditional healing through herbs have been the experienced of many countries since ages, as they were generally whispered to be non toxic natural products. Contemporary medicine is more concern for the cure of diseases but remnants indifferent to health conservation. There is an urgent need to combine the best elements of traditional medicine and modern medicine to improve the health care system of human kind. For the reason that of the rapid progress of herbal drug an increasing need is felt to standardize the herbal products. It is needed to develop the scientific protocols such as SOP and pharmacopoeial standards of the poly herbal drug Majoon-a- Aaradkhurma. Majoon-e-aradkhurma is traditionally used to controls spermatorrhoea and nocturnal emissions and it increases the density of semen and sperm count. The pharmacognostical evaluation comprises of phytochemical screening, physical constants such as ash values, extractive values, heavy metal, pesticide residue and aflatoxin analysis. Study revealed that heavy metals such as lead, cadmium, mercury and arsenic were not detected in the drug. Pesticide residues and aflatoxin were also absent in the drug. The data evolved in the present work help to fix the scientific standards for Majoon-a- Aaradkhurma.